Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutics Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown 2193, South Africa.
Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutics Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown 2193, South Africa.
Carbohydr Polym. 2019 Oct 15;222:114988. doi: 10.1016/j.carbpol.2019.114988. Epub 2019 Jun 10.
This study introduces a novel approach in fabricating bioplatforms with favourable physical, chemical, and mechanical properties for wound dressing applications. The approach employs a three-step method; partial-crosslinking of polymers into soft macromatrices, lyophilization, and pulverization of those macromatrices to obtain polymer particles with improved properties. For investigation of this approach, the ionic polysaccharides, sodium alginate and chitosan were partially crosslinked with calcium chloride and sodium tripolyphosphate, respectively, followed by interpolymer complexation (IPC) for formation of the bioplatform. The formulations displayed good thermal stability with enhanced water uptake. The IPC exhibited water uptake of 4343.4% over 24 h and displayed 78% biodegradation over 14 days, which was superior to that of a commercial alginate-based wound dressing (1612.56% swelling and 16.26% biodegradation). The bioplatform thus possessed promising fluid-absorptivity and biodegradability, for potential application as a wound therapeutic system.
本研究提出了一种新颖的方法，用于制造具有良好物理、化学和机械性能的生物平台，适用于伤口敷料应用。该方法采用三步法；聚合物的部分交联形成软大分子，冷冻干燥，以及大分子的粉碎，以获得具有改善性能的聚合物颗粒。为了研究这种方法，离子多糖海藻酸钠和壳聚糖分别与氯化钙和三聚磷酸钠部分交联，然后进行聚合物间络合（IPC）形成生物平台。配方显示出良好的热稳定性和增强的吸水性。IPC 在 24 小时内的吸水率为 4343.4%，14 天内的降解率为 78%，优于商业海藻酸钠基伤口敷料（1612.56%的溶胀和 16.26%的降解）。因此，该生物平台具有良好的流体吸收性和生物降解性，有望作为伤口治疗系统的应用。
