Satish Swathi, Tharmavaram Maithri, Rawtani Deepak
Institute of Research & Development, Gujarat Forensic Sciences University, Gandhinagar, Gujarat, India.
Nanobiomedicine (Rij). 2019 Jul 12;6:1849543519863625. doi: 10.1177/1849543519863625. eCollection 2019 Jan-Dec.
The arena of biomedical science has long been in quest of innovative mediums for diagnostic and therapeutic applications. The latest being the use of nanomaterials for such applications, thereby giving rise to the branch of nanomedicine. Halloysite nanotubes (HNTs) are naturally occurring tubular clay nanomaterials, made of aluminosilicate kaolin sheets rolled several times. The aluminol and siloxane groups on the surface of HNT facilitate the formation of hydrogen bonding with the biomaterials onto its surface. These properties render HNT pivotal in diverse range of applications, such as in environmental sciences, waste-water treatment, dye removal, nanoelectronics and fabrication of nanocomposites, catalytic studies, as glass coatings or anticorrosive coatings, in cosmetics, as flame retardants, stimuli response, and forensic sciences. The specific properties of HNT also lead to numerous applications in biomedicine and nanomedicine, namely drug delivery, gene delivery, tissue engineering, cancer and stem cells isolation, and bioimaging. In this review, recent developments in the use of HNT for various nanomedicinal applications have been discussed.
长期以来，生物医学科学领域一直在寻求用于诊断和治疗应用的创新介质。最新的是将纳米材料用于此类应用，从而催生了纳米医学分支。埃洛石纳米管（HNTs）是天然存在的管状粘土纳米材料，由铝硅酸盐高岭土片层多次卷曲而成。HNT表面的铝醇和硅氧烷基团有助于与表面的生物材料形成氢键。这些特性使HNT在多种应用中发挥关键作用，如环境科学、废水处理、染料去除、纳米电子学和纳米复合材料的制造、催化研究、作为玻璃涂层或防腐涂层、在化妆品中、作为阻燃剂、刺激响应以及法医学等。HNT的特殊性质还使其在生物医学和纳米医学中有众多应用，即药物递送、基因递送、组织工程、癌症和干细胞分离以及生物成像。在本综述中，讨论了HNT在各种纳米医学应用中的最新进展。
