Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.
College of Medicine, Southwest Jiaotong University, Chengdu, 610031, China.
Small. 2020 Mar;16(9):e1902262. doi: 10.1002/smll.201902262. Epub 2019 Jul 19.
Combination chemotherapy with time-programmed administration of multiple drugs is a promising method for cancer treatment. However, realizing time-programmed release of combined drugs from a single carrier is still a great challenge in enhanced cancer therapy. Here, an implantable trilayer structured fiber device is developed to achieve time-programmed release of combined drugs for synergistic treatment of breast cancer. The fiber device is prepared by a modified microfluidic-electrospinning technique. The glycerol solution containing chemotherapy agent doxorubicin (Dox) forms the internal periodic cavities of the fiber, and poly(l-lactic acid) and poly(ε-caprolactone) containing the angiogenesis inhibitor apatinib (Apa) form the double walls of the fiber. Rapid release of Dox can be obtained by adjusting the wall thickness of the cavities, meanwhile sustained release of Apa is achieved through the slow degradation of the fiber matrix. After the fiber device is implanted subcutaneously near to the implanted solid tumor of mice, an excellent synergistic therapeutic effect is achieved through time-programmed release of the combined dual drugs. The fiber device provides a platform to sequentially co-deliver dual or multiple drugs for enhanced combined therapeutic efficacy.
联合化疗中多种药物的时间程序给药是癌症治疗的一种很有前途的方法。然而，从单一载体中实现联合药物的时间程序释放仍然是增强癌症治疗的一个巨大挑战。在这里，开发了一种可植入的三层结构纤维装置，以实现联合药物的时间程序释放，用于协同治疗乳腺癌。纤维装置是通过改良的微流控-静电纺丝技术制备的。含有化疗药物阿霉素（Dox）的甘油溶液形成纤维的内部周期性腔，而含有血管生成抑制剂阿帕替尼（Apa）的聚（L-乳酸）和聚（ε-己内酯）形成纤维的双层壁。通过调整腔的壁厚可以获得 Dox 的快速释放，同时通过纤维基质的缓慢降解实现 Apa 的持续释放。将纤维装置皮下植入小鼠的植入性实体瘤附近后，通过联合双药物的时间程序释放实现了优异的协同治疗效果。该纤维装置为顺序共递输送双重或多种药物提供了一个平台，以增强联合治疗效果。
