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Topical delivery of mTOR inhibitor halts scarring.mTOR抑制剂的局部递送可阻止瘢痕形成。
J Dermatol Sci. 2019 Aug;95(2):76-79. doi: 10.1016/j.jdermsci.2019.06.008. Epub 2019 Jul 4.
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A novel application of topical rapamycin formulation, an inhibitor of mTOR, for patients with hypomelanotic macules in tuberous sclerosis complex.雷帕霉素局部制剂（一种mTOR抑制剂）在结节性硬化症色素减退斑患者中的新应用。
Arch Dermatol. 2012 Jan;148(1):138-9. doi: 10.1001/archderm.148.1.138.
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Topical use of mammalian target of rapamycin inhibitors in dermatology: A systematic review with meta-analysis.局部应用雷帕霉素靶蛋白抑制剂在皮肤科的应用：系统评价与荟萃分析。
J Am Acad Dermatol. 2019 Mar;80(3):735-742. doi: 10.1016/j.jaad.2018.10.070.
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mTOR inhibitor sirolimus negatively impacts in vitro fertilization outcomes.mTOR抑制剂西罗莫司对体外受精结果有负面影响。
J Assist Reprod Genet. 2019 May;36(5):947-950. doi: 10.1007/s10815-019-01439-4. Epub 2019 Mar 25.
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Laser-Assisted Delivery of Topical Rapamycin: mTOR Inhibition for Birt-Hogg-Dube Syndrome.雷帕霉素局部给药的激光辅助递送：用于Birt-Hogg-Dube综合征的mTOR抑制
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Topical mTOR (mechanistic target of rapamycin) inhibitor therapy in facial angiofibroma.面部血管纤维瘤的局部雷帕霉素靶蛋白（mTOR）抑制剂治疗
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Sirolimus therapy in the treatment of pseudomyogenic hemangioendothelioma.西罗莫司治疗假性肌源性血管内皮瘤
Pediatr Blood Cancer. 2018 Feb;65(2). doi: 10.1002/pbc.26781. Epub 2017 Aug 26.
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Topical application of rapamycin ointment ameliorates Dermatophagoides farina body extract-induced atopic dermatitis in NC/Nga mice.雷帕霉素软膏局部应用可改善粉尘螨提取物诱导的NC/Nga小鼠特应性皮炎。
Exp Dermatol. 2014 Aug;23(8):568-72. doi: 10.1111/exd.12463. Epub 2014 Jul 16.
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Mammalian target of rapamycin inhibitor-associated stomatitis in hematopoietic stem cell transplantation patients receiving sirolimus prophylaxis for graft-versus-host disease.接受西罗莫司预防移植物抗宿主病的造血干细胞移植患者中雷帕霉素哺乳动物靶点抑制剂相关口腔炎
Biol Blood Marrow Transplant. 2015 Mar;21(3):503-8. doi: 10.1016/j.bbmt.2014.11.680. Epub 2014 Dec 5.
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Efficacy of re-challenging metastatic renal cell carcinoma with mTOR inhibitors.使用mTOR抑制剂再次挑战转移性肾细胞癌的疗效。
Acta Oncol. 2011 Oct;50(7):1135-6. doi: 10.3109/0284186X.2011.592149. Epub 2011 Jul 5.

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Mammalian Target Rapamycin Inhibition as a Therapeutic Target for Prevention of Proliferative Vitreoretinopathy.抑制哺乳动物雷帕霉素靶蛋白作为预防增殖性玻璃体视网膜病变的治疗靶点
JAMA Ophthalmol. 2025 Aug 7. doi: 10.1001/jamaophthalmol.2025.2497.
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Feeling the Heat. Mapping the Epigenetic Modifications of Histone during Burn Wound Healing.感受热度。绘制烧伤创面愈合过程中组蛋白的表观遗传修饰图谱。
J Burn Care Res. 2024 Mar 4;45(2):499-507. doi: 10.1093/jbcr/irad187.
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Skin wound healing triggers epigenetic modifications of histone H4.皮肤伤口愈合会引发组蛋白H4的表观遗传修饰。
J Transl Med. 2020 Mar 26;18(1):138. doi: 10.1186/s12967-020-02303-1.
4
BMAL1 Modulates Epidermal Healing in a Process Involving the Antioxidative Defense Mechanism.BMAL1 通过抗氧化防御机制调节表皮愈合过程。
Int J Mol Sci. 2020 Jan 30;21(3):901. doi: 10.3390/ijms21030901.

本文引用的文献

1
Ozone oil promotes wound healing by increasing the migration of fibroblasts via PI3K/Akt/mTOR signaling pathway.臭氧油通过激活 PI3K/Akt/mTOR 信号通路促进成纤维细胞迁移从而促进伤口愈合。
Biosci Rep. 2017 Nov 9;37(6). doi: 10.1042/BSR20170658. Print 2017 Dec 22.
2
Rapamycin: one drug, many effects.雷帕霉素：一种药物，多种效应。
Cell Metab. 2014 Mar 4;19(3):373-9. doi: 10.1016/j.cmet.2014.01.001. Epub 2014 Feb 6.
3
Periostin responds to mechanical stress and tension by activating the MTOR signaling pathway.骨膜蛋白通过激活mTOR信号通路对机械应力和张力作出反应。
PLoS One. 2013 Dec 13;8(12):e83580. doi: 10.1371/journal.pone.0083580. eCollection 2013.
4
Exploiting PI3K/mTOR signaling to accelerate epithelial wound healing.利用 PI3K/mTOR 信号通路加速上皮伤口愈合。
Oral Dis. 2013 Sep;19(6):551-8. doi: 10.1111/odi.12070. Epub 2013 Feb 4.
5
Wnt/β-catenin pathway forms a negative feedback loop during TGF-β1 induced human normal skin fibroblast-to-myofibroblast transition.Wnt/β-catenin 通路在 TGF-β1 诱导的人正常皮肤成纤维细胞向肌成纤维细胞转分化过程中形成负反馈环。
J Dermatol Sci. 2012 Jan;65(1):38-49. doi: 10.1016/j.jdermsci.2011.09.012. Epub 2011 Oct 17.
6
Accelerated wound healing by mTOR activation in genetically defined mouse models.通过 mTOR 激活在遗传定义的小鼠模型中加速伤口愈合。
PLoS One. 2010 May 13;5(5):e10643. doi: 10.1371/journal.pone.0010643.
7
Human skin wounds: a major and snowballing threat to public health and the economy.人类皮肤创伤：对公共健康和经济的重大且不断加剧的威胁。
Wound Repair Regen. 2009 Nov-Dec;17(6):763-71. doi: 10.1111/j.1524-475X.2009.00543.x.
8
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.在生命后期喂食雷帕霉素可延长基因异质小鼠的寿命。
Nature. 2009 Jul 16;460(7253):392-5. doi: 10.1038/nature08221. Epub 2009 Jul 8.
9
Chemoprevention and treatment of experimental Cowden's disease by mTOR inhibition with rapamycin.雷帕霉素抑制mTOR对实验性考登病的化学预防和治疗作用
Cancer Res. 2008 Sep 1;68(17):7066-72. doi: 10.1158/0008-5472.CAN-08-0922.
10
Wound repair and regeneration.伤口修复与再生。
Nature. 2008 May 15;453(7193):314-21. doi: 10.1038/nature07039.

Topical delivery of mTOR inhibitor halts scarring.

作者信息

Webber Liana P, Yip Brian, Nascimento Filho Carlos H V do, Park Ha B, Castilho Rogerio M, Squarize Cristiane H

机构信息

Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, 48109-1078, USA.

Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, 48109-1078, USA; The Michigan Medicine Rogel Cancer Center, University of Michigan, Ann Arbor, MI, 48109, USA.

出版信息

J Dermatol Sci. 2019 Aug;95(2):76-79. doi: 10.1016/j.jdermsci.2019.06.008. Epub 2019 Jul 4.

DOI:10.1016/j.jdermsci.2019.06.008
PMID:31324514
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7117794/
Abstract
摘要