Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, 8091, Zurich, Switzerland.
Institute of Medical Virology, University of Zurich, 8057, Zurich, Switzerland.
Nat Commun. 2019 Jul 19;10(1):3193. doi: 10.1038/s41467-019-10884-9.
The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host characteristics associated with reservoir size and long-term dynamics in 1,057 individuals on suppressive antiretroviral therapy for a median of 5.4 years. At the population level, the reservoir decreases with diminishing differences over time, but increases in 26.6% of individuals. Viral blips and low-level viremia are significantly associated with slower reservoir decay. Initiation of ART within the first year of infection, pretreatment viral load, and ethnicity affect reservoir size, but less so long-term dynamics. Viral blips and low-level viremia are thus relevant for reservoir and cure studies.
HIV-1 储存库是治愈的主要障碍。我们在此评估了在中位数为 5.4 年的时间内接受抑制性抗逆转录病毒治疗的 1057 个人中与储存库大小和长期动态相关的病毒和宿主特征。在人群水平上，随着时间的推移，储存库的差异逐渐减少，但仍有 26.6%的个体的储存库增加。病毒突增和低水平病毒血症与储存库衰减速度较慢显著相关。感染后第一年开始接受 ART、治疗前病毒载量和种族影响储存库大小，但对长期动态的影响较小。因此，病毒突增和低水平病毒血症与储存库和治愈研究相关。
