J Clin Invest. 2019 Jul 22;129(8):2983-2993. doi: 10.1172/JCI124618.
Skin and intestinal epithelial barriers play a pivotal role in protecting underlying tissues from harsh external environments. The protective role of these epithelia is, in part, dependent on a remarkable capacity to restore barrier function and tissue homeostasis after injury. In response to damage, epithelial wounds repair by a series of events that integrate epithelial responses with those of resident and infiltrating immune cells including neutrophils and monocytes/macrophages. Compromise of this complex interplay predisposes to development of chronic nonhealing wounds, contributing to morbidity and mortality of many diseases. Improved understanding of crosstalk between epithelial and immune cells during wound repair is necessary for development of better pro-resolving strategies to treat debilitating complications of disorders ranging from inflammatory bowel disease to diabetes. In this Review we focus on epithelial and innate immune cell interactions that mediate wound healing and restoration of tissue homeostasis in the skin and intestine.
皮肤和肠道上皮屏障在保护深层组织免受恶劣外部环境影响方面发挥着关键作用。这些上皮的保护作用部分依赖于其在受伤后恢复屏障功能和组织内稳态的非凡能力。为了应对损伤，上皮伤口通过一系列事件进行修复，这些事件将上皮的反应与常驻和浸润免疫细胞（包括中性粒细胞和单核细胞/巨噬细胞）的反应整合在一起。这种复杂相互作用的失调会导致慢性非愈合性伤口的发展，从而导致许多疾病的发病率和死亡率上升。更好地了解上皮细胞和免疫细胞在伤口修复过程中的相互作用，对于开发更好的促解决策略以治疗从炎症性肠病到糖尿病等疾病的致残并发症是必要的。在这篇综述中，我们重点讨论了介导皮肤和肠道伤口愈合和组织内稳态恢复的上皮细胞和先天免疫细胞的相互作用。
