Service de Radiothérapie, Centre François Baclesse, Caen, France.
Bureau CORASSO, France.
Head Neck. 2019 Oct;41(10):3719-3732. doi: 10.1002/hed.25877. Epub 2019 Jul 22.
The incidence of cancer during pregnancy is low but is slightly increasing. Data on incidence and etiology of head and neck (HN) cancers in pregnant women are rare. We evaluated the frequency, tumor type, associated factors, and specific biomarkers in HN cancers occurring in pregnant (and peripartum) women.
A systematic literature search was performed on PubMed, for any HN tumor site occurring in pregnant women.
Sixty cases of HN cancers occurring during pregnancy were identified. Most of them were oral cavity cancers. Relationships with oncogenic viruses, hormonal disturbance, and shift in maternal immunity profile were identified.
Carcinogenesis of HN cancers in pregnant women may be led by different cancer type-specific hallmarks. Relevance of these etiological factors with respect to treatments and birth control recommendations is being investigated by the REFCOR in an ambispective study.
怀孕期间癌症的发病率较低，但呈轻微上升趋势。有关孕妇头颈部（HN）癌症的发病率和病因的数据很少。我们评估了在孕妇（和围产期）中发生的 HN 癌症的频率、肿瘤类型、相关因素和特定生物标志物。
在 PubMed 上进行了系统的文献检索，以查找任何发生在孕妇中的 HN 肿瘤部位。
确定了 60 例 HN 癌症病例，其中大多数为口腔癌。发现与致癌病毒、激素紊乱和母体免疫谱变化有关。
孕妇 HN 癌症的发生可能是由不同的癌症类型特异性特征引起的。REFCOR 正在一项前瞻性研究中调查这些病因因素与治疗和避孕建议的相关性。
