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安纳托利亚 14 种鼠尾草属植物中迷迭香酸和鼠尾草酸含量及相关抗氧化和抗糖尿病活性的研究。

Rosmarinic and carnosic acid contents and correlated antioxidant and antidiabetic activities of 14 Salvia species from Anatolia.

机构信息

Istanbul Technical University, Department of Chemistry, Maslak, Istanbul, Turkey.

Balıkesir University, Department of Biology Education, Merkez, Balikesir, Turkey.

出版信息

J Pharm Biomed Anal. 2019 Oct 25;175:112763. doi: 10.1016/j.jpba.2019.07.011. Epub 2019 Jul 8.

Abstract

Herbal medicine has been used worldwide as an alternative treatment. Salvia genus is one of the most remarked herbs which is traditionally used in the treatment of many diseases. Therefore, it is a crucial issue to reveal the chemical and biological profiles of different Salvia species. Rosmarinic and carnosic acid are the most well-known bioactive components generally accepted as the main antioxidant compounds in Salvia. This study firstly aims the determination of rosmarinic and carnosic acid contents of 14 Anatolian Salvia species by a simple and rapid capillary electrophoresis method. Moreover, the antioxidant activities and total phenolic contents of the Salvia samples were investigated. α-Glucosidase enzyme inhibitory effects of the samples were tested concerning their antidiabetic activities. The rosmarinic acid contents in the samples were well-correlated with the bioactivities.

摘要

草药在世界范围内被用作替代疗法。鼠尾草属是最著名的草药之一,传统上用于治疗许多疾病。因此,揭示不同鼠尾草属植物的化学和生物学特征是一个至关重要的问题。迷迭香酸和鼠尾草酸是最著名的生物活性成分,通常被认为是鼠尾草中的主要抗氧化化合物。本研究首先旨在通过一种简单快速的毛细管电泳法测定 14 种安纳托利亚鼠尾草属植物中迷迭香酸和鼠尾草酸的含量。此外,还研究了鼠尾草样品的抗氧化活性和总酚含量。测试了样品对α-葡萄糖苷酶的抑制作用,以考察其抗糖尿病活性。样品中的迷迭香酸含量与生物活性密切相关。

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