Rodrigo Alberto, Ojeda Jorge L, Vega Sonia, Sanchez-Gracia Oscar, Lanas Angel, Isla Dolores, Velazquez-Campoy Adrian, Abian Olga
Medical Oncology Department, Hospital Arnau de Vilanova, 25198 Lleida, Spain.
Department of Statistical Methods, Universidad de Zaragoza, 50009 Zaragoza, Spain.
Cancers (Basel). 2019 Jul 19;11(7):1012. doi: 10.3390/cancers11071012.
Risk population screening programs are instrumental for advancing cancer management and reducing economic costs of therapeutic interventions and the burden of the disease, as well as increasing the survival rate and improving the quality of life for cancer patients. Lung cancer, with high incidence and mortality rates, is not excluded from this situation. The success of screening programs relies on many factors, with some of them being the appropriate definition of the risk population and the implementation of detection techniques with an optimal discrimination power and strong patient adherence. Liquid biopsy based on serum or plasma detection of circulating tumor cells or DNA/RNA is increasingly employed nowadays, but certain limitations constrain its wide application. In this work, we present a new implementation of thermal liquid biopsy (TLB) for lung cancer patients. TLB provides a prediction score based on the ability to detect plasma/serum proteome alterations through calorimetric thermograms that strongly correlates with the presence of lung cancer disease (91% accuracy rate, 90% sensitivity, 92% specificity, diagnostic odds ratio 104). TLB is a quick, minimally-invasive, low-risk technique that can be applied in clinical practice for evidencing lung cancer, and it can be used in screening and monitoring actions.
风险人群筛查项目有助于推进癌症管理，降低治疗干预的经济成本和疾病负担，同时提高癌症患者的生存率并改善其生活质量。肺癌的发病率和死亡率都很高，也不例外。筛查项目的成功依赖于许多因素，其中包括对风险人群的恰当定义以及采用具有最佳鉴别能力且患者依从性高的检测技术。如今，基于血清或血浆检测循环肿瘤细胞或DNA/RNA的液体活检越来越多地被采用，但某些局限性限制了其广泛应用。在这项工作中，我们展示了一种针对肺癌患者的热液体活检（TLB）新方法。TLB通过量热热谱图检测血浆/血清蛋白质组变化的能力提供一个预测分数，该分数与肺癌疾病的存在密切相关（准确率91%，灵敏度90%，特异性92%，诊断比值比104）。TLB是一种快速、微创、低风险的技术，可应用于临床实践以诊断肺癌，并且可用于筛查和监测行动。
