Laboratories of Marine New Drugs, REDONE Seoul, Seoul 08594, Korea.
Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea.
Mar Drugs. 2019 Jul 19;17(7):422. doi: 10.3390/md17070422.
Mycousfurans ( and ), two new usnic acid congeners, along with (-)-mycousnine (), (-)-placodiolic acid (), and (+)-usnic acid (), were isolated using high-performance liquid chromatography-ultraviolet (HPLC-UV)-guided fractionation of extracts of sp. isolated from a marine sediment. The planar structures of and were elucidated using 1D and 2D NMR spectra. The relative configurations of the stereogenic carbons of and were established via analysis of their nuclear Overhauser spectroscopy (NOESY) spectra, and their absolute configurations were determined using a comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compounds and were found to have antibacterial activity, showing moderate activity against and .
我的表亲呋喃（和），两个新的 usnic 酸同系物，以及（-）-mycousnine（），（-）-placodiolic 酸（）和（+）-usnic 酸（），是通过对从海洋沉积物中分离的 sp.的提取物进行高效液相色谱-紫外（HPLC-UV）引导的分步分离而分离出来的。使用 1D 和 2D NMR 光谱阐明了 和 的平面结构。通过分析它们的核奥弗豪瑟光谱（NOESY）谱，确定了 和 的立体碳的相对构型，并且通过比较实验和计算的电子圆二色谱（ECD）谱确定了它们的绝对构型。发现化合物 和 具有抗菌活性，对 和 表现出中等活性。
