子囊霉素A，一种由从深海沉积物中分离出的子囊菌属Ind19F07产生的新型柠檬霉素类似物。
Ascomycotin A, a new citromycetin analogue produced by Ascomycota sp. Ind19F07 isolated from deep sea sediment.
作者信息
Tian Yong-qi, Lin Xiu-ping, Liu Juan, Kaliyaperumal Kumaravel, Ai Wen, Ju Zhi-ran, Yang Bin, Wang Junfeng, Yang Xian-wen, Liu Yonghong
机构信息
a Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences , Guangzhou 510301 , P.R. China.
出版信息
Nat Prod Res. 2015;29(9):820-6. doi: 10.1080/14786419.2014.988620. Epub 2014 Dec 24.
A new citromycetin analogue, ascomycotin A (1), together with eight known compounds, wortmannilactone E (2), orcinol (3), orsellinic acid (4), isosclerone (5), (3R,4S)-( - )-4-hydroxymellein (6), diorcinol (7), chaetocyclinone B (8) and 2,5-dimethoxy-3,6-di(p-methoxypheny1)-1,4-benzoquinone (9), was isolated from the fungal strain Ascomycota sp. Ind19F07, which was isolated from the deep sea sediment of the Indian Ocean. The structures of the compounds were established by spectroscopic data including 1D and 2D NMR and HR-ESI-MS. Compounds (1-9) were evaluated for antibacterial activity.
从印度洋深海沉积物中分离得到的真菌菌株印度子囊菌属（Ascomycota sp.）Ind19F07中，分离出一种新的柠檬霉素类似物——子囊霉素A（1），以及8种已知化合物，分别为渥曼青霉素E（2）、苔黑酚（3）、苔色酸（4）、异硬脂酮（5）、(3R,4S)-( - )-4-羟基水合氧化麦角硫因（6）、二苔黑酚（7）、枝孢环酮B（8）和2,5-二甲氧基-3,6-二（对甲氧基苯基）-1,4-苯醌（9）。通过包括一维和二维核磁共振以及高分辨电喷雾电离质谱在内的光谱数据确定了这些化合物的结构。对化合物（1 - 9）进行了抗菌活性评估。
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