类风湿关节炎中的α1抗胰蛋白酶（PI）同种异型
alpha 1 Antitrypsin (PI) allotypes in rheumatoid arthritis.
作者信息
Sanders P A, Thomson W, Browne D A, Dyer P A, Grennan D M
出版信息
Ann Rheum Dis. 1986 Jun;45(6):450-3. doi: 10.1136/ard.45.6.450.
Abstract
alpha 1 Antitrypsin (PI) phenotypes were defined in 144 patients with rheumatoid arthritis (RA) and in 223 normal controls. The frequencies of the rare F, S, and Z variants were similar in RA and control groups. No relationships were found between PI allotypes and rheumatoid disease severity or autoantibody titre. The PI M1M2 phenotype was increased in frequency in the RA group, and phenotype frequencies in DR4 positive and negative disease were similar. These results support the suggestion that genes on the 14th chromosome which are linked to PI predispose to RA.
摘要
在144例类风湿性关节炎（RA）患者和223名正常对照者中确定了α1抗胰蛋白酶（PI）表型。RA组和对照组中罕见的F、S和Z变异体的频率相似。未发现PI别型与类风湿疾病严重程度或自身抗体滴度之间存在关联。RA组中PI M1M2表型的频率增加，DR4阳性和阴性疾病中的表型频率相似。这些结果支持这样的观点，即与PI连锁的第14号染色体上的基因易患RA。
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引用本文的文献
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Ann Rheum Dis. 1988 Oct;47(10):843-8. doi: 10.1136/ard.47.10.843.
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Ann Rheum Dis. 1989 Jan;48(1):48-52. doi: 10.1136/ard.48.1.48.
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Springer Semin Immunopathol. 1992;14(1):59-78. doi: 10.1007/BF00197132.
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