Søyseth V, Kongerud J, Ekstrand J, Boe J
Hydro Aluminium, Health Department, Ardal Aluminium Plant, Norway.
Thorax. 1994 Oct;49(10):984-9. doi: 10.1136/thx.49.10.984.
The relation between plasma fluoride levels and bronchial responsiveness was investigated in a longitudinal study in aluminium potroom workers who reported work-related asthmatic symptoms.
From a cross-sectional respiratory survey, 26 men who reported work-related asthmatic symptoms on a validated questionnaire were selected for repeated measurements of bronchial responsiveness to methacholine. Regular analyses of plasma fluoride levels were performed. Exposure to fluoride and total particulates was assessed from routine surveillance of the workplace. Bronchial responsiveness was expressed as the dose-response slope of the line through the origin and last data point.
A positive association was found between bronchial responsiveness and plasma fluoride levels, such that an increase in the plasma fluoride level of 10 ng/ml was associated with an increase in the dose-response slope by a factor of 1.11 (95% confidence interval 1.05 to 1.17). Plasma fluoride levels were associated with the total atmospheric fluoride concentration in mg/m3 (beta = 28.1), but not with total particulates in the environment.
Bronchial responsiveness in aluminium potroom workers reporting work-related asthmatic symptoms appears to be related to plasma levels of fluoride. The underlying mechanism is, however, unknown.
在一项针对报告有与工作相关哮喘症状的铝电解车间工人的纵向研究中，对血浆氟水平与支气管反应性之间的关系进行了调查。
从一项横断面呼吸调查中，选择26名在经过验证的问卷上报告有与工作相关哮喘症状的男性，对其支气管对乙酰甲胆碱的反应性进行重复测量。定期分析血浆氟水平。通过对工作场所的常规监测评估氟和总颗粒物的暴露情况。支气管反应性以通过原点和最后一个数据点的直线的剂量反应斜率表示。
发现支气管反应性与血浆氟水平之间存在正相关，即血浆氟水平每增加10 ng/ml，剂量反应斜率增加1.11倍（95%置信区间为1.05至1.17）。血浆氟水平与大气中氟的总浓度（mg/m3）相关（β = 28.1），但与环境中的总颗粒物无关。
报告有与工作相关哮喘症状的铝电解车间工人的支气管反应性似乎与血浆氟水平有关。然而，其潜在机制尚不清楚。
