Positivo University, Curitiba, Paraná, Brazil; Federal University of Parana, Curitiba, Paraná, Brazil.
Federal University of Parana, Curitiba, Paraná, Brazil.
J Craniomaxillofac Surg. 2019 Aug;47(8):1300-1305. doi: 10.1016/j.jcms.2019.05.003. Epub 2019 May 10.
Orthognathic surgery is a procedure that is performed for the correction of dentofacial deformities and can lead to a change in an individual's anxiety levels. Anxiety is a multifactorial condition in which hormones and genes play an important role. This study aimed to evaluate if gender and genetic polymorphisms in estrogen receptor alpha (ESR1) and beta (ESR2) are associated with anxiety levels in patients undergoing orthognathic surgery. In this longitudinal observational study, 44 patients were included. Anxiety level assessments were performed at three time periods: 2 days before the surgical procedure and 1 and 6 months postoperatively, using the State-Trait Anxiety Inventory Scale. Gender, age, and facial profile were also evaluated. Additionally, a saliva sample from each individual was collected for the genotypic evaluation of ESR1 (rs2234693 and rs9340799) and ESR2 (rs1256049 and rs4986938) using real time polymerase chain reaction. Data were analyzed with a significance level of 0.05. There was a decrease in trait-anxiety and state-anxiety when comparing the preoperative measurements with those obtained 1 and 6 months postoperatively (p < 0.05). Females were more anxious than males at each time point during the study (p < 0.05). The genetic polymorphism rs9340799 in ESR1 was associated with state-anxiety during the preoperative period (p = 0.046). In conclusion, an individual's gender and genetic polymorphism in ESR1 are associated with anxiety in orthognathic surgery patients.
正颌手术是一种用于矫正牙颌面畸形的手术，可导致个体焦虑水平的变化。焦虑是一种多因素的疾病，其中激素和基因起着重要作用。本研究旨在评估接受正颌手术的患者中，性别和雌激素受体 alpha (ESR1) 和 beta (ESR2) 的基因多态性是否与焦虑水平相关。在这项纵向观察性研究中，纳入了 44 名患者。使用状态-特质焦虑量表 (State-Trait Anxiety Inventory Scale) 在三个时间段评估焦虑水平：手术前 2 天和术后 1 个月和 6 个月。还评估了性别、年龄和面部轮廓。此外，从每个个体采集唾液样本，使用实时聚合酶链反应对 ESR1(rs2234693 和 rs9340799) 和 ESR2(rs1256049 和 rs4986938) 的基因型进行评估。数据分析的显著性水平为 0.05。与术前测量相比，术后 1 个月和 6 个月时特质焦虑和状态焦虑均降低(p<0.05)。在研究期间的每个时间点，女性都比男性更焦虑(p<0.05)。ESR1 中的遗传多态性 rs9340799 与术前期间的状态焦虑相关 (p=0.046)。总之，个体的性别和 ESR1 中的遗传多态性与正颌手术患者的焦虑有关。
