Institute of Medical Sciences, Tzu Chi University, Taiwan.
Int J Urol. 2012 Nov;19(11):995-1001. doi: 10.1111/j.1442-2042.2012.03095.x. Epub 2012 Jul 9.
To assess overactive bladder and its component symptoms among patients with type 2 diabetes mellitus and to explore whether higher glycosylated hemoglobin and other factors increase the risk of overactive bladder symptoms.
A total of 279 diabetes mellitus patients from our outpatient clinic, and 578 age- and sex-matched subjects without diabetes mellitus from public health centers were enrolled from May to September of 2010. The collected data included overactive bladder and its component symptoms measured by using the Overactive Bladder Symptom Score, and collecting demographic and clinical data. Overactive bladder was defined as total Overactive Bladder Symptom Score ≥3 and urgency score ≥2 (once a week or more).
Diabetes mellitus patients had a significantly higher proportion of overactive bladder symptoms/urgency compared with the controls (28.0% vs 16.3%, odds ratio 2.03, 95% confidence interval 1.44-2.86), as well as nocturia (48.0% vs 39.1%, odds ratio 1.44, 95% confidence interval 1.08-1.93). There were no significant effects of diabetes mellitus on urge urinary incontinence (14.0% vs 10.9%, odds ratio 1.32, 95% confidence interval 0.86-2.04) and daytime frequency (26.9% vs 32.4%, odds ratio 0.77, 95% confidence interval 0.56-1.05). After adjusting for all variables, high glycosylated hemoglobin levels were significantly associated with overactive bladder/urgency (odds ratio 1.24, 95% confidence interval 1.06-1.45), urge urinary incontinence (odds ratio 1.20, 95% confidence interval 1.00-1.45) and nocturia (odds ratio 1.17, 95% confidence interval 1.01-1.35).
Patients with type 2 mellitus present more overactive bladder symptoms/urgency and nocturia than controls. Among diabetic patients, higher glycosylated hemoglobin level represents an independent predictor of overactive bladder /urgency, urge urinary incontinence and nocturia.
评估 2 型糖尿病患者中膀胱过度活动症及其各组成症状，并探讨糖化血红蛋白升高和其他因素是否会增加膀胱过度活动症症状的发生风险。
2010 年 5 月至 9 月，连续纳入我院门诊的 279 例糖尿病患者和同期 578 例年龄、性别匹配的非糖尿病健康体检者。采用膀胱过度活动症症状评分表（Overactive Bladder Symptom Score，OABSS）评估膀胱过度活动症及其各组成症状，收集人口学和临床资料。膀胱过度活动症定义为 OABSS 总分≥3 分且尿急评分≥2 分（每周≥1 次）。
糖尿病患者的膀胱过度活动症症状/尿急发生率显著高于对照组（28.0%比 16.3%，比值比 2.03，95%置信区间 1.442.86），夜尿症（48.0%比 39.1%，比值比 1.44，95%置信区间 1.081.93）也更常见。糖尿病对急迫性尿失禁（14.0%比 10.9%，比值比 1.32，95%置信区间 0.862.04）和日间尿频（26.9%比 32.4%，比值比 0.77，95%置信区间 0.561.05）的影响无统计学意义。校正所有变量后，高糖化血红蛋白水平与膀胱过度活动症/尿急（比值比 1.24，95%置信区间 1.061.45）、急迫性尿失禁（比值比 1.20，95%置信区间 1.001.45）和夜尿症（比值比 1.17，95%置信区间 1.01~1.35）显著相关。
与非糖尿病者相比，2 型糖尿病患者的膀胱过度活动症症状/尿急和夜尿症更为常见。在糖尿病患者中，高糖化血红蛋白水平是膀胱过度活动症/尿急、急迫性尿失禁和夜尿症的独立预测因素。
