Chen Hongliang, Wen Yating, Li Zhongyu
Institute of Pathogenic Biology, Hengyang Medical College, Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, China.
Department of Clinical Microbiology Laboratory, Chenzhou No. 1 People's Hospital, Chenzhou, China.
Front Microbiol. 2019 Jul 3;10:1412. doi: 10.3389/fmicb.2019.01412. eCollection 2019.
As obligate intracellular bacterial pathogens, members of the genera are the pivotal triggers for a wide range of infections, which can lead to blinding trachoma, pelvic inflammation, and respiratory diseases. Because of their restricted parasitism inside eukaryotic cells, the pathogens have to develop multiple strategies for adaptation with the hostile intracellular environment-intrinsically present in all host cells-to survive. The strategies that are brought into play at different stages of chlamydial development mainly involve interfering with diverse innate immune responses, such as innate immune recognition, inflammation, apoptosis, autophagy, as well as the manipulation of innate immune cells to serve as potential niches for chlamydial replication. This review will focus on the innate immune responses against chlamydial infection, highlighting the underlying molecular mechanisms used by the spp. to counteract host innate immune defenses. Insights into these subtle pathogenic mechanisms not only provide a rationale for the augmentation of immune responses against chlamydial infection but also open avenues for further investigation of the molecular mechanisms driving the survival of these clinically important pathogens in host innate immunity.
作为专性胞内细菌病原体，该属成员是多种感染的关键触发因素，可导致致盲性沙眼、盆腔炎和呼吸道疾病。由于它们在真核细胞内寄生受限，病原体必须制定多种策略来适应所有宿主细胞内固有的恶劣细胞内环境以生存。衣原体发育不同阶段所采用的策略主要涉及干扰多种先天免疫反应，如先天免疫识别、炎症、凋亡、自噬，以及操纵先天免疫细胞作为衣原体复制的潜在小生境。本综述将聚焦于针对衣原体感染的先天免疫反应，重点介绍该属物种用于对抗宿主先天免疫防御的潜在分子机制。深入了解这些微妙的致病机制不仅为增强针对衣原体感染的免疫反应提供了理论依据，也为进一步研究驱动这些临床重要病原体在宿主先天免疫中生存的分子机制开辟了道路。
