Jones Michael E, Ganzer Christine A, Bennett Deanne, Finizio Andrea
Lexington Plastic Surgeons, New York, N.Y.
Hunter College, New York, N.Y.
Plast Reconstr Surg Glob Open. 2019 May 3;7(5):e2212. doi: 10.1097/GOX.0000000000002212. eCollection 2019 May.
Keloids are benign proliferative scars that often occur among individuals of color, and are thought to be the result of excessive collagen deposition that occurs after injury to the skin. The treatment of these scars is difficult with often poor outcomes. This study aimed to evaluate the effectiveness of surgical excision followed by in-office superficial radiation therapy (SRT) as a method to improve keloid remission.
Participants for this study were recruited from June 2016 through February 2017 with 48 subjects enrolled and completed this study. All keloids were surgically resected and participants received 3 consecutive days of a customized dose of SRT, with a maximum cumulative dosage of 18 Gy. Patients were followed over the course of 12 months to monitor outcomes.
In this cohort, we found 39 (81%) to have achieved successful remission with 9 (19%) being classified as refractory. There were no adverse effects or medical complications reported as a part of this study.
Study outcomes support the clinical benefits of surgical excision followed by SRT as a practical and efficient treatment for keloids.
瘢痕疙瘩是一种良性增生性瘢痕，常见于有色人种个体，被认为是皮肤受伤后胶原蛋白过度沉积的结果。这些瘢痕的治疗困难，效果往往不佳。本研究旨在评估手术切除后联合门诊浅表放射治疗（SRT）作为改善瘢痕疙瘩缓解的一种方法的有效性。
本研究的参与者于2016年6月至2017年2月招募，共有48名受试者入组并完成了本研究。所有瘢痕疙瘩均接受手术切除，参与者连续3天接受定制剂量的SRT，最大累积剂量为18 Gy。对患者进行了12个月的随访以监测结果。
在该队列中，我们发现39例（81%）实现了成功缓解，9例（19%）被归类为难治性。作为本研究的一部分，未报告有不良反应或医学并发症。
研究结果支持手术切除后联合SRT作为瘢痕疙瘩实用且有效的治疗方法的临床益处。
