微小RNA在中风恢复中的作用。
Role of microRNAs in stroke recovery.
作者信息
Bansal Agam, Prathap Rana, Gupta Samiksha, Chaurasia Aditi, Chaudhary Pooja
机构信息
Department of Internal Medicine, M.B.B.S., All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
出版信息
J Family Med Prim Care. 2019 Jun;8(6):1850-1854. doi: 10.4103/jfmpc.jfmpc_296_19.
Abstract
Ischemic stroke is an important cause of morbidity and mortality across the globe. It is associated with physical, social, and economic disability. Immediately after the stroke, there is a critical period of spontaneous recovery during which there is maximal return to near normal. Following stroke, there is a period of neurogenesis, angiogenesis, axonal growth, and synaptic plasticity. There have been several studies focusing on neuroprotection and enhancing recovery following stroke. However, translation of these into clinical practice has been disappointing. The role of microRNAs in treatment of cancer has been well documented, but studying their role in stroke recovery has been minimal. MicroRNAs serve as critical mediators of recovery following stroke. In this review article, we discuss the role of microRNAs in stroke recovery.
摘要
缺血性中风是全球发病和死亡的重要原因。它与身体、社会和经济残疾相关。中风后立即进入自发恢复的关键时期，在此期间可最大程度地恢复至接近正常状态。中风后会经历一段神经发生、血管生成、轴突生长和突触可塑性的时期。已有多项研究聚焦于中风后的神经保护和促进恢复。然而，将这些研究成果转化为临床实践却令人失望。微小RNA在癌症治疗中的作用已有充分记载，但对其在中风恢复中作用的研究却很少。微小RNA是中风后恢复的关键调节因子。在这篇综述文章中，我们讨论了微小RNA在中风恢复中的作用。
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