Graduate School of Sports and Health Science, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka, 810-0180, Japan.
J Physiol Sci. 2010 Sep;60(5):325-30. doi: 10.1007/s12576-010-0100-4. Epub 2010 Jun 24.
We investigated the association between the angiotensin I-converting enzyme (ACE) gene insertion (I)/deletion (D) polymorphism and endurance running performance in Japanese elite runners, including several Olympic athletes. The frequency of the I/I genotype was not significantly higher and the frequency of the D/D genotype was not significantly lower in elite runners compared with non-athletes. However, the frequency of the I/D genotype tended to be lower in elite runners than in non-athletes. The best performance was significantly higher for runners with the D/D genotype than for those with the I/I genotype, and the average running speed was significantly higher for those with the combined D/D + I/D genotypes than for those with the I/I genotype. There were no I/I genotypes among the five fastest marathon runners. These results suggest that the D allele of the ACE gene I/D polymorphism is associated with a high level of human endurance.
我们研究了血管紧张素转换酶（ACE）基因插入（I）/缺失（D）多态性与日本精英跑者（包括一些奥运选手）的耐力跑表现之间的关系。与非运动员相比，精英跑者中 I/I 基因型的频率并没有显著升高，D/D 基因型的频率也没有显著降低。然而，精英跑者中 I/D 基因型的频率趋于降低。D/D 基因型的跑者比 I/I 基因型的跑者表现更好，具有 D/D+I/D 基因型的跑者的平均跑步速度也显著高于 I/I 基因型的跑者。在五名最快的马拉松跑者中没有 I/I 基因型。这些结果表明，ACE 基因 I/D 多态性的 D 等位基因与高水平的人类耐力有关。
