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沸石咪唑酯骨架-8 作为 pH 敏感的纳米载体用于“三氧化二砷”药物传递。

Zeolitic Imidazolate Framework-8 as pH-Sensitive Nanocarrier for "Arsenic Trioxide" Drug Delivery.

机构信息

Chair of Solid State and Materials Chemistry, Institute of Physics, University of Augsburg, Universitaetsstraße 1, 86159, Augsburg, Germany.

Pediatric Hematology and Oncology, University Children's Hospital Muenster, Albert-Schweitzer-Campus 1, 48149, Muenster, Germany.

出版信息

Chemistry. 2019 Oct 11;25(57):13189-13196. doi: 10.1002/chem.201902599. Epub 2019 Sep 13.

DOI:10.1002/chem.201902599
PMID:31336004
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6856809/
Abstract

Previous results revealed that arsenic trioxide might be used as promising therapeutic agent for the treatment of some solid tumours as atypical teratoid rhabdoid tumours (ATRT). However, in order to become an approved drug for solid tumour treatment, the active formulation has to get more efficient and feasible-but at the same time less toxic. One of the possibilities to achieve this dichotomy is to use nanomedicine tools. Herein, we report on the Zn-based metal-organic framework ZIF-8 (Zeolitic Imidazolate Framework-8) which turned out to be a promising candidate for the delivery of As species. It conjointly features a high drug loading capacity and a prominent pH-triggered release behaviour. As -loaded ZIF-8 nanoparticles coated and non-coated with polyethylene glycol were studied by XRPD, IR, Raman, TGA, TEM, EDX, CHN-elemental analysis, sorption analysis and ICP-OES, and their cytotoxicity was evaluated in vitro.

摘要

先前的研究结果表明，三氧化二砷可能被用作治疗某些实体瘤（如非典型畸胎样横纹肌样肿瘤）的有前途的治疗药物。然而，为了成为治疗实体瘤的批准药物，活性制剂必须更有效、更可行，但同时毒性更低。实现这种二分法的一种可能性是使用纳米医学工具。在这里，我们报告了基于锌的金属有机骨架 ZIF-8（沸石咪唑酯骨架-8），它被证明是递送砷物种的有前途的候选物。它还具有高药物负载能力和突出的 pH 触发释放行为。我们通过 X 射线粉末衍射（XRPD）、红外（IR）、拉曼（Raman）、热重分析（TGA）、透射电子显微镜（TEM）、能量色散 X 射线能谱（EDX）、元素分析（CHN）、吸附分析和电感耦合等离子体-发射光谱法（ICP-OES）研究了负载砷的 ZIF-8 纳米粒子以及用和不用聚乙二醇包覆的纳米粒子，并在体外评估了它们的细胞毒性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6152/6856809/9af073325870/CHEM-25-13189-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6152/6856809/2d155e22ac57/CHEM-25-13189-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6152/6856809/b8f42eee0293/CHEM-25-13189-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6152/6856809/2e5fa8dcf816/CHEM-25-13189-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6152/6856809/2278ba232f2d/CHEM-25-13189-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6152/6856809/9af073325870/CHEM-25-13189-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6152/6856809/2d155e22ac57/CHEM-25-13189-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6152/6856809/b8f42eee0293/CHEM-25-13189-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6152/6856809/2e5fa8dcf816/CHEM-25-13189-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6152/6856809/2278ba232f2d/CHEM-25-13189-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6152/6856809/9af073325870/CHEM-25-13189-g005.jpg

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