Mamizadeh Mina, Tardeh Zainab, Azami Milad
Department of Dermatology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran.
Diabetes Metab Syndr. 2019 Mar-Apr;13(2):1405-1412. doi: 10.1016/j.dsx.2019.01.009. Epub 2019 Jan 19.
Psoriasis is an immune-mediated chronic inflammatory skin disease with unknown etiology. Current findings demonstrate that psoriatic patients are at higher risk of other systemic disorders such as diabetes mellitus. The present study was conducted to evaluate the association between psoriasis and diabetes mellitus.
The current study was conducted based on preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines. Using MeSH keywords we searched online databases of PubMed, Scopus, Web of Science, Science Direct, Embase, CINAHL, Cochrane Library, EBSCO and Google scholar search engine and the reference list of the retrieved articles until June 2018. Heterogeneity among studies was assessed using Cochran's Q test and I index and the random effects model was used to estimate Odds Ratio (OR) and 95% confidence interval (CI). Data were analyzed using Comprehensive Meta-Analysis (CMA) software version 2.
Analysis of 38 eligible studies involving 922870 cases and 12808071 controls suggested the estimated OR to be 1.69 (95% Confidence Interval [CI]: 1.51-1.89; P < 0.001). Subgroup analysis was conducted based on study design and country of study and was significant (test for subgroup differences: P = 0.025 and P < 0.001, respectively).
Our study indicated the significant association between psoriasis and diabetes. Therefore, psoriasis is a systemic disorder and other comorbidities should be considered in the management of patients with psoriasis.
银屑病是一种病因不明的免疫介导的慢性炎症性皮肤病。目前的研究结果表明，银屑病患者患其他全身性疾病如糖尿病的风险更高。本研究旨在评估银屑病与糖尿病之间的关联。
本研究是根据系统评价和荟萃分析的首选报告项目（PRISMA）指南进行的。使用医学主题词（MeSH）关键词，我们检索了PubMed、Scopus、科学网、Science Direct、Embase、CINAHL、Cochrane图书馆、EBSCO和谷歌学术搜索引擎等在线数据库以及检索到的文章的参考文献列表，检索截至2018年6月。使用 Cochr an's Q检验和I指数评估研究之间的异质性，并使用随机效应模型估计优势比（OR）和95%置信区间（CI）。使用综合荟萃分析（CMA）软件版本2进行数据分析。
对38项符合条件的研究进行分析，涉及922870例病例和12808071例对照，估计OR为1.69（95%置信区间[CI]：1.51 - 1.89；P < 0.001）。根据研究设计和研究国家进行亚组分析，结果具有显著性（亚组差异检验：P分别为0.025和P < 0.001）。
我们的研究表明银屑病与糖尿病之间存在显著关联。因此，银屑病是一种全身性疾病，在银屑病患者的管理中应考虑其他合并症。
