Dipartimento di Scienze Motorie e del Benessere, Università di Napoli Parthenope, via Medina 40, 80133 Napoli, Italy.
Int J Environ Res Public Health. 2019 Jul 22;16(14):2607. doi: 10.3390/ijerph16142607.
Epigenetics describes how both lifestyle and environment may affect human health through the modulation of genome functions and without any change to the DNA nucleotide sequence. The discovery of several epigenetic mechanisms and the possibility to deliver epigenetic marks in cells, gametes, and biological fluids has opened up new perspectives in the prevention, diagnosis, and treatment of human diseases. In this respect, the depth of knowledge of epigenetic mechanisms is fundamental to preserving health status and to developing targeted interventions. In this minireview, we summarize the epigenetic modulation of the gene in order to provide an example of epigenetic regulation in health and disease.
表观遗传学描述了生活方式和环境如何通过调节基因组功能来影响人类健康，而无需改变 DNA 核苷酸序列。几种表观遗传机制的发现以及在细胞、配子和生物液中传递表观遗传标记的可能性，为人类疾病的预防、诊断和治疗开辟了新的视角。在这方面，对表观遗传机制的深入了解对于维持健康状态和开发有针对性的干预措施至关重要。在这个小综述中，我们总结了 基因的表观遗传调控，以期提供一个健康和疾病中表观遗传调控的范例。
