Mitra Sarmistha, Dash Raju
Department of Pharmacy, University of Chittagong, Chittagong 4331, Bangladesh.
Department of Biochemistry and Biotechnology, University of Science and Technology Chittagong, Chittagong 4202, Bangladesh.
Evid Based Complement Alternat Med. 2018 Feb 26;2018:8324696. doi: 10.1155/2018/8324696. eCollection 2018.
Among all types of cancer, breast cancer is one of the most challenging diseases, which is responsible for a large number of cancer related deaths. Hormonal therapy, surgery, chemotherapy, and radiotherapy have been used as treatment of breast cancer, for a very long time. Due to severe side effects and multidrug resistance, these treatment approaches become increasingly ineffective. However, adoption of complementary treatment approach can be a big solution for this situation, as it is evident that compounds derived from natural source have a great deal of anticancer activity. Natural compounds can fight against aggressiveness of breast cancer, inhibit cancerous cell proliferation, and modulate cancer related pathways. A large number of research works are now focusing on the natural and dietary compounds and trying to find out new and more effective treatment strategies for the breast cancer patients. In this review, we discussed some significant natural chemical compounds with their mechanisms of actions, which can be very effective against the breast cancer and can be more potent by their proper modifications and further clinical research. Future research focusing on the natural anti-breast-cancer agents can open a new horizon in breast cancer treatment, which will play a great role in enhancing the survival rate of breast cancer patients.
在所有类型的癌症中,乳腺癌是最具挑战性的疾病之一,导致大量与癌症相关的死亡。长期以来,激素疗法、手术、化疗和放疗一直被用作乳腺癌的治疗方法。由于严重的副作用和多药耐药性,这些治疗方法越来越无效。然而,采用辅助治疗方法可能是解决这一情况的一大办法,因为很明显,天然来源的化合物具有大量抗癌活性。天然化合物可以对抗乳腺癌的侵袭性,抑制癌细胞增殖,并调节与癌症相关的途径。现在大量的研究工作都集中在天然和膳食化合物上,并试图为乳腺癌患者找到新的、更有效的治疗策略。在这篇综述中,我们讨论了一些重要的天然化合物及其作用机制,它们对乳腺癌可能非常有效,通过适当的修饰和进一步的临床研究可能会更有效。未来针对天然抗乳腺癌药物的研究可以为乳腺癌治疗开辟新的前景,这将在提高乳腺癌患者的生存率方面发挥重要作用。