Morahan P S, Klykken P C, Smith S H, Harris L S, Munson A E
Infect Immun. 1979 Mar;23(3):670-4. doi: 10.1128/iai.23.3.670-674.1979.
Previous investigations from our laboratories have demonstrated that cannabinoids possess immunosuppressive properties. The present studies were designed to determine whether these agents decrease host resistance to infections with Listeria monocytogenes and herpes simplex virus type 2. Host resistance was measured by changes in the 50% lethal dose of the pathogen in cannabinoid-treated and control mice. The effect of cannabinoids on resistance to L. monocytogens was dose dependent. Delta-9-tetrhydrocannabinol at doses of 38, 75, and 150 mg/kg suppressed resistance to infection by 10-, 17-, and 657-fold, respectively. Marijuana extract was less active but significantly reduced resistance to L. moncytogenes at all tested doses. Resistance to systemic herpes simplex virus type 2 infection was decreased 96-fold by delta-9-tetrahydrocannabinol, although marijuana extract was inactive. The doses and regimen of treatment with cannabinoids that produced significant decreases in host resistance were similar to those which caused suppression of delayed-type hypersensitivity to sheep erythrocytes. The possible mechanisms and public health aspects of the decreased host resistance produced by marijuana extract and its cannabinoids are discussed.
我们实验室之前的研究表明，大麻素具有免疫抑制特性。本研究旨在确定这些物质是否会降低宿主对单核细胞增生李斯特菌和2型单纯疱疹病毒感染的抵抗力。通过测量大麻素处理组和对照组小鼠中病原体50%致死剂量的变化来评估宿主抵抗力。大麻素对抵抗单核细胞增生李斯特菌的作用具有剂量依赖性。剂量为38、75和150mg/kg的Δ9-四氢大麻酚分别将感染抵抗力抑制了10倍、17倍和657倍。大麻提取物的活性较低，但在所有测试剂量下均显著降低了对单核细胞增生李斯特菌的抵抗力。尽管大麻提取物无活性，但Δ9-四氢大麻酚使对全身性2型单纯疱疹病毒感染的抵抗力降低了96倍。导致宿主抵抗力显著下降的大麻素治疗剂量和方案与引起对绵羊红细胞迟发型超敏反应抑制的剂量和方案相似。本文讨论了大麻提取物及其大麻素导致宿主抵抗力下降的可能机制和公共卫生问题。
