Inada Natalia Mayumi, Buzzá Hilde Harb, Leite Marieli Fernanda Martins, Kurachi Cristina, Trujillo Jose Roberto, de Castro Cynthia Aparecida, Carbinatto Fernanda Mansano, Lombardi Welington, Bagnato Vanderlei Salvador
São Carlos Institute of Physics, University of Sao Paulo, São Carlos 13566-590, Brazil.
Woman Health Ambulatory, Uniara 14801-308, Brazil.
Pharmaceuticals (Basel). 2019 Jul 12;12(3):107. doi: 10.3390/ph12030107.
(1) Background: Cervical cancer is the third most commonly diagnosed cancer and the fourth leading cause of cancer death in women worldwide. The highest incidence rates are in Africa, followed by South-Central Asia and South America. According to the Brazilian National Institute of Cancer (INCA), 16,370 new cases of cervical cancer were estimated for each year of the biennium of 2018-2019. About 90% of cervical cancers originate from the malignant progression of cervical intraepithelial neoplasia (CIN) which is classified based on cytohistological characteristics (low- and high-grade lesions). The present study reports the long-term effectiveness of topical photodynamic therapy (PDT) for CIN grades 1 and 2/3 with up to two years of follow up. (2) Methods: A total of 56 patients with CIN 1, ten with CIN 2, and 14 patients for the placebo group were enrolled in this study. (3) Results: 75% ( = 42) of CIN 1 patients presented a complete response to PDT and only 23.2% ( = 13) of recurrence, progression, and/or lesions remaining two years after PDT. For CIN 2/3 patients, 90% were observed to be cured after one and two years of follow up. (4) Conclusions: PDT presented best results two years after a non-invasive, fast, and low-cost procedure and in comparison with the placebo group, preventing the progression of cervical intraepithelial neoplasia and preserving the cervix.
(1) 背景：宫颈癌是全球女性中第三大最常被诊断出的癌症，也是癌症死亡的第四大主要原因。发病率最高的地区是非洲，其次是中南亚和南美洲。根据巴西国家癌症研究所（INCA）的数据，2018 - 2019两年期内每年估计有16370例宫颈癌新发病例。约90%的宫颈癌起源于宫颈上皮内瘤变（CIN）的恶性进展，CIN根据细胞组织学特征（低级别和高级别病变）进行分类。本研究报告了局部光动力疗法（PDT）对1级和2/3级CIN长达两年随访的长期疗效。(2) 方法：本研究共纳入56例CIN 1患者、10例CIN 2患者和14例作为安慰剂组的患者。(3) 结果：75%（n = 42）的CIN 1患者对PDT呈现完全缓解，PDT后两年仅有23.2%（n = 13）复发、进展和/或仍有病变。对于CIN 2/3患者，随访一年和两年后观察到90%已治愈。(4) 结论：PDT在一种无创、快速且低成本的治疗后两年呈现出最佳效果，并且与安慰剂组相比，可预防宫颈上皮内瘤变的进展并保留宫颈。
