Arola H, Koivula T, Jokela H, Jauhiainen M, Keyriläinen O, Ahola T, Uusitalo A, Isokoski M
Dept. of Public Health, University of Tampere, Finland.
Scand J Gastroenterol. 1988 Apr;23(3):351-7. doi: 10.3109/00365528809093878.
The aim of this study was to continue our previously published work and to compare the different indirect diagnostic methods for hypolactasia with the lactase to sucrase ratio obtained by jejunal biopsy. The following tests were performed in 63 adult patients: the breath hydrogen test, the lactose tolerance test with ethanol (serum galactose measurement after oral lactose load with ethanol), the urinary lactose tolerance test (urinary galactose measurement after oral lactose load with ethanol), and the strip test (like the former but using a special test strip for urinary galactose). Specificities of all these tests were good (96-98%). The 3-h breath hydrogen test was less sensitive (69%) than the other methods (81-94%). The strip test is recommended for the general practitioner for the diagnosis of this common cause of abdominal complaints.
本研究的目的是延续我们之前发表的工作，并将不同的乳糖酶缺乏间接诊断方法与通过空肠活检获得的乳糖酶与蔗糖酶比值进行比较。对63名成年患者进行了以下测试：呼气氢试验、乙醇乳糖耐量试验（口服乳糖负荷加乙醇后测定血清半乳糖）、尿乳糖耐量试验（口服乳糖负荷加乙醇后测定尿半乳糖）以及试纸条试验（与前者类似，但使用用于尿半乳糖的特殊试纸条）。所有这些测试的特异性都很好（96 - 98%）。3小时呼气氢试验的敏感性（69%）低于其他方法（81 - 94%）。建议全科医生使用试纸条试验来诊断这种常见的腹部不适病因。
