Wessel Maximilian J, Draaisma Laurijn R, Morishita Takuya, Hummel Friedhelm C
Defitech Chair of Clinical Neuroengineering, Center for Neuroprosthetics and Brain Mind Institute, Swiss Federal Institute of Technology (EPFL), Geneva, Switzerland.
Defitech Chair of Clinical Neuroengineering, Clinique Romande de Réadaptation, Center for Neuroprosthetics and Brain Mind Institute, Swiss Federal Institute of Technology (EPFL Valais), Sion, Switzerland.
Front Neurosci. 2019 Jul 9;13:703. doi: 10.3389/fnins.2019.00703. eCollection 2019.
Cortical function is dependent on the balance between excitatory and inhibitory influences. In the human motor cortex, surrogates of these interactions can be measured , non-invasively with double-pulse transcranial magnetic stimulation (TMS). To compare results from data acquired with different available setups and bring data together, it is inevitable to determine whether different TMS setups lead to comparable or differential results. We assessed and compared short intracortical inhibition (SICI) and intracortical facilitation (ICF) testing four different experimental conditions. SICI and ICF were studied with different stimulators (Magstim BiStim or MagVenture MagPro X100), waveforms (monophasic or biphasic), current directions (anterior-posterior or posterior-anterior) at interstimulus intervals (ISIs) of 1, 3, 10, 15 ms. We were not able to detect differences for SICI and ICF, when comparing the tested conditions, except for 3 ms SICI in which the anterior-posterior current direction led to stronger modulation. Correlation analysis suggested comparability for 3 ms SICI for the Magstim monophasic posterior-anterior condition with both tested MagVenture conditions. 3 ms SICI data sets obtained with two different, commonly used stimulators (Magstim BiStim or MagVenture MagPro X100) with conventionally used stimulation parameters are largely comparable. This may allow the combination of data sets in an open science view.
皮质功能取决于兴奋性和抑制性影响之间的平衡。在人类运动皮质中，这些相互作用的替代指标可以通过双脉冲经颅磁刺激（TMS）进行非侵入性测量。为了比较不同可用设置获取的数据结果并整合数据，确定不同的TMS设置是否会导致可比或不同的结果是不可避免的。我们评估并比较了短皮质内抑制（SICI）和皮质内易化（ICF），测试了四种不同的实验条件。在1、3、10、15毫秒的刺激间隔（ISI）下，使用不同的刺激器（Magstim BiStim或MagVenture MagPro X100）、波形（单相或双相）、电流方向（前后或后前）对SICI和ICF进行了研究。在比较测试条件时，我们未能检测到SICI和ICF的差异，除了3毫秒的SICI，其中前后电流方向导致更强的调制。相关性分析表明，Magstim单相后前条件下3毫秒的SICI与两种测试的MagVenture条件具有可比性。使用两种不同的常用刺激器（Magstim BiStim或MagVenture MagPro X100）和传统刺激参数获得的3毫秒SICI数据集在很大程度上具有可比性。这可能允许在开放科学视角下整合数据集。
