Zakian Amir, Mami Sajad, Nouri Mohammad, Jalali Seyedeh Misagh, Tehrani-Sharif Meysam
Department of Clinical Sciences, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran.
Department of Laboratory and Clinical Sciences, Faculty of Veterinary Medicine, Ilam University, Ilam, Iran.
Vet Res Forum. 2019 Spring;10(2):173-176. doi: 10.30466/vrf.2018.85534.2115. Epub 2019 Jun 15.
A 3-year-old pregnant Arabian mare was referred to the Veterinary Teaching Hospital of Shahid Chamran University of Ahvaz with a history of bleeding and rodenticide ingestion. The results of paraclinical examinations showed severe normocytic and normochromic anemia, decreased serum total protein, albumin, and fibrinogen concentrations, increased serum total bilirubin, urea, and creatinine concentrations, as well as increased serum aspartate aminotransferase and creatine kinase activity. Three days after treatment, all the clinical signs were resolved, however, fetus abortion occurred. In order to confirm the suspected cause of abortion and toxicosis, high-performance liquid chromatography was performed on serum sample of mare and liver tissue of the aborted fetus and toxicosis was confirmed. Poisoning with brodifacoum is considered as an important and lethal poisoning for both human being and animals. To our knowledge, this is the first report of spontaneous toxicosis and abortion with brodifacoum. Brodifacoum toxicosis can be effectively managed with early diagnosis, good paraclinical examinations and appropriate treatment.
一匹3岁怀孕的阿拉伯母马因有出血和摄入杀鼠剂的病史，被转诊至阿瓦士沙希德·查姆兰大学兽医学院教学医院。临床检查结果显示有严重的正细胞正色素性贫血、血清总蛋白、白蛋白和纤维蛋白原浓度降低、血清总胆红素、尿素和肌酐浓度升高，以及血清天冬氨酸转氨酶和肌酸激酶活性增加。治疗三天后，所有临床症状均得到缓解，但发生了胎儿流产。为了确认流产和中毒的疑似原因，对母马的血清样本和流产胎儿的肝脏组织进行了高效液相色谱分析，中毒得到证实。溴敌隆中毒被认为是对人类和动物都重要且致命的中毒。据我们所知，这是溴敌隆自发中毒和流产的首例报告。通过早期诊断、良好的临床检查和适当的治疗，溴敌隆中毒可以得到有效控制。
