Department of Clinical Dental Sciences, Polytechnic University of Marche, Ancona, Italy.
Department of Life and Environmental Sciences, Polytechnic University of Marche, Ancona, Italy.
Diabetes Metab J. 2019 Dec;43(6):893-897. doi: 10.4093/dmj.2018.0254. Epub 2019 Jun 27.
Cardiovascular diseases represent the leading cause of death and moderate physical exercise is associated with a reduction in cardiovascular risk. The aim of the study was to evaluate the correlation between the amount of exercise recorded daily by a wearable gravitometer for 3 months and selected biochemical and clinical parameters. Nineteen sedentary type 2 diabetics were recruited and distributed into three homogenous groups, low, medium, and high exercise, according to the level of physical exercise monitored and expressed as MOVEs. Data showed an inverse correlation between MOVEs and oxidative stress indexes and a significant improvement in paraoxonase-1 activities and endothelial functionality. Decrease of visceral/total adipose tissue ratio, systolic blood pressure and a down-regulation of the inflammatory microRNA-146a in high exercise group were observed. Finally, a decrease of glycosylated hemoglobin and an up-regulation of the angiogenic microRNA-130a in medium exercise one was obtained. In this study, precise daily monitoring permitted to underline the importance of the amount of physical activity to counteract some cardiovascular risk factors persisting in diabetes. Finally, it identifies new microRNA biomarkers for future investigation on the same topic.
心血管疾病是导致死亡的主要原因，适度的体育锻炼与降低心血管风险有关。本研究旨在评估佩戴重力计 3 个月记录的日常运动量与选定生化和临床参数之间的相关性。招募了 19 名久坐的 2 型糖尿病患者，并根据监测到的运动量和表示为 MOVEs 的运动量将他们分为低、中、高运动量三组。数据显示，MOVEs 与氧化应激指标呈负相关，对人对氧磷酶-1 活性和内皮功能有显著改善作用。在高运动量组中观察到内脏/总脂肪组织比、收缩压下降和促炎 microRNA-146a 下调。最后，在中运动量组中观察到糖化血红蛋白下降和血管生成 microRNA-130a 上调。在这项研究中，精确的日常监测强调了适量的体育活动对抵消糖尿病患者持续存在的一些心血管危险因素的重要性。最后，它确定了新的 microRNA 生物标志物，用于同一主题的进一步研究。
