Department of Biomedical Engineering, National University of Singapore, Singapore, 117583, Singapore.
Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, Singapore, 117599, Singapore.
Adv Mater. 2020 Apr;32(15):e1902133. doi: 10.1002/adma.201902133. Epub 2019 Jul 24.
Wearable electronics have revolutionized the way physiological parameters are sensed, detected, and monitored. In recent years, advances in flexible and stretchable hybrid electronics have created emergent properties that enhance the compliance of devices to our skin. With their unobtrusive attributes, skin conformable sensors enable applications toward real-time disease diagnosis and continuous healthcare monitoring. Herein, critical perspectives of flexible hybrid electronics toward the future of digital health monitoring are provided, emphasizing its role in physiological sensing. In particular, the strategies within the sensor composition to render flexibility and stretchability while maintaining excellent sensing performance are considered. Next, novel approaches to the functionalization of the sensor for physical or biochemical stimuli are extensively covered. Subsequently, wearable sensors measuring physical parameters such as strain, pressure, temperature, as well as biological changes in metabolites and electrolytes are reported. Finally, their implications toward early disease detection and monitoring are discussed, concluding with a future perspective into the challenges and opportunities in emerging wearable sensor designs for the next few years.
可穿戴电子产品彻底改变了生理参数的感知、检测和监测方式。近年来，柔性和可拉伸混合电子产品的进步创造了新兴特性，增强了设备对我们皮肤的适应性。凭借其不引人注目的特性，与皮肤贴合的传感器能够实现实时疾病诊断和持续医疗保健监测等应用。在此，提供了有关柔性混合电子产品对数字健康监测未来的关键观点，强调了其在生理感应方面的作用。特别是，考虑了在保持出色感应性能的同时使传感器具有柔韧性和拉伸性的策略。接下来，广泛介绍了对物理或生化刺激进行传感器功能化的新方法。随后，报道了测量应变、压力、温度等物理参数以及代谢物和电解质中生物变化的可穿戴传感器。最后，讨论了它们在早期疾病检测和监测方面的意义，最后对未来几年新兴可穿戴传感器设计的挑战和机遇进行了展望。
