Faculty of Pharmacy, Department of Basic Pharmaceutical Sciences, Hacettepe University, Ankara, Turkey.
J Drug Target. 2020 Mar;28(3):225-244. doi: 10.1080/1061186X.2019.1648479. Epub 2019 Aug 13.
Early researchers focussed on developing stimuli-responsive liposomes in order to manipulate drug release at the site of action or under certain conditions. In recent times, a great deal of efforts has been made to modify the surface of liposomes with ligands for the purpose of achieving targeted drug delivery. Due to the morphology of liposomes, their surfaces can be engineered by attaching molecules such as oligosaccharides, peptides, antibodies, antigens and oligonucleotides to the bilayer structure. Over the years, a number of techniques including the use of covalent and non-covalent linkages have been utilised in designing ligand-liposome conjugates. In this review, various strategies for the functionalisation of liposomes as well as the different types of ligand-liposome conjugates have been discussed. Finally, the pros and cons of conjugation in liposomes are concisely summarised.
早期的研究人员专注于开发对刺激有响应的脂质体，以便在作用部位或在某些条件下控制药物释放。最近，人们做了大量努力来用配体修饰脂质体的表面，以实现靶向药物传递。由于脂质体的形态，它们的表面可以通过将分子如寡糖、肽、抗体、抗原和寡核苷酸附着到双层结构上来进行工程设计。多年来，包括使用共价和非共价键在内的多种技术已被用于设计配体-脂质体缀合物。在这篇综述中，讨论了脂质体功能化的各种策略以及不同类型的配体-脂质体缀合物。最后，简明总结了脂质体中缀合的优缺点。
