Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, Milano 20133, Italy.
Dipartimento di Scienze farmaceutiche, DISFARM, Università degli Studi di Milano, Via Venezian 21, Milano 20133, Italy.
Drug Discov Today. 2021 Aug;26(8):1794-1824. doi: 10.1016/j.drudis.2021.05.010. Epub 2021 May 29.
Liposomes are amphipathic lipidic supramolecular aggregates that are able to encapsulate and carry molecules of both hydrophilic and hydrophobic nature. They have been widely used as in vivo drug delivery systems for some time because they offer features such as synthetic flexibility, biodegradability, biocompatibility, low immunogenicity, and negligible toxicity. In recent years, the chemical modification of liposomes has paved the way to the development of smart liposome-based drug delivery systems, which are characterized by even more tunable and disease-directed features. In this review, we highlight the different types of chemical modification introduced to date, with a particular focus on internal stimuli-responsive liposomes and prodrug activation.
脂质体是两亲性脂质超分子聚集体，能够包裹和携带亲水和疏水性质的分子。它们已被广泛用作体内药物传递系统一段时间，因为它们具有合成灵活性、生物降解性、生物相容性、低免疫原性和几乎无毒的特性。近年来，脂质体的化学修饰为智能脂质体药物传递系统的发展铺平了道路，这些系统具有更可调谐和针对疾病的特征。在这篇综述中，我们重点介绍了迄今为止引入的不同类型的化学修饰，特别是内部刺激响应脂质体和前药激活。
