Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Department of Epidemiology and Biostatistics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Am J Clin Nutr. 2019 Nov 1;110(5):1119-1130. doi: 10.1093/ajcn/nqz141.
Depressive symptoms and impaired physical functioning are prevalent among older adults. Supplementation with vitamin D might improve both conditions, particularly in persons with low vitamin D status.
The D-Vitaal study primarily aimed to investigate the effect of vitamin D supplementation on depressive symptoms, functional limitations, and physical performance in a high-risk older population with low vitamin D status. Secondary aims included examining the effect of vitamin D supplementation on anxiety symptoms, cognitive functioning, mobility, handgrip strength, and health-related quality of life.
This study was a randomized placebo-controlled trial with 155 participants aged 60-80 y who had clinically relevant depressive symptoms, ≥1 functional limitations, and serum 25-hydroxyvitamin D [25(OH)D] concentrations of 15-50/70 nmol/L (depending on season). Participants received 1200 IU/d vitamin D3 (n = 77) or placebo tablets (n = 78) for 12 mo. Serum 25(OH)D was measured at baseline and 6 mo; outcomes were assessed at baseline, 6 mo, and 12 mo. Linear mixed-models analyses were conducted to assess the effect of the intervention.
The supplementation increased serum 25(OH)D concentrations in the intervention group to a mean ± SD of 85 ± 16 nmol/L compared with 43 ± 18 nmol/L in the placebo group after 6 mo (P < 0.001). No relevant differences between the treatment groups were observed regarding depressive symptoms, functional limitations, physical performance, or any of the secondary outcomes.
Supplementation with 1200 IU/d vitamin D for 12 mo had no effect on depressive symptoms and physical functioning in older persons with relatively low vitamin D status, clinically relevant depressive symptoms, and poor physical functioning. This trial is registered with the Netherlands Trial Register (www.trialregister.nl) under NTR3845.
抑郁症状和身体机能障碍在老年人中普遍存在。补充维生素 D 可能会改善这两种情况，尤其是在维生素 D 水平较低的人群中。
D-Vitaal 研究主要旨在调查维生素 D 补充对低维生素 D 状态的高风险老年人群中抑郁症状、功能限制和身体机能的影响。次要目的包括研究维生素 D 补充对焦虑症状、认知功能、移动能力、手握力和健康相关生活质量的影响。
这是一项随机安慰剂对照试验，纳入了 155 名年龄在 60-80 岁之间、有临床相关抑郁症状、≥1 种功能限制且血清 25-羟维生素 D [25(OH)D]浓度为 15-50/70 nmol/L（取决于季节）的参与者。参与者接受 1200 IU/d 维生素 D3（n=77）或安慰剂片剂（n=78）治疗 12 个月。在基线和 6 个月时测量血清 25(OH)D；在基线、6 个月和 12 个月时评估结局。采用线性混合模型分析评估干预的效果。
补充剂使干预组的血清 25(OH)D 浓度在 6 个月时平均增加到 85 ± 16 nmol/L，而安慰剂组为 43 ± 18 nmol/L（P<0.001）。治疗组之间在抑郁症状、功能限制、身体机能或任何次要结局方面均无显著差异。
在维生素 D 状态相对较低、有临床相关抑郁症状和身体机能较差的老年人中，补充 1200 IU/d 维生素 D 12 个月对抑郁症状和身体机能无影响。该试验在荷兰临床试验注册中心（www.trialregister.nl）注册，注册号为 NTR3845。
