Moradi Kh, Sabbagh Alvani A A, Poelman D
Color & Polymer Research Center, Amirkabir University of Technology (Tehran Polytechnic), P.O. Box 15875-4413, Tehran, Iran.
Department of Polymer Engineering and Color Technology, Amirkabir University of Technology (Tehran Polytechnic), P.O. Box 15875-4413, Tehran, Iran.
Materials (Basel). 2019 Jul 23;12(14):2339. doi: 10.3390/ma12142339.
Nanostructured hydroxyapatite (HA) is a new class of biocompatible fillers which has been recently utilized in bio hybrid materials by virtue of its excellent tissue bioactivity and biocompatibility. However, the need for higher thermal stability, solubility, surface bioactivity, radiopacity, and remineralization ability suggests a divalent cation substitution of HA for use in light curable dental restorative composites. In this work, structural and optical properties of Sr-doped hydroxyapatite were studied using first-principle calculations based on density functional theory (DFT). Next, Sr-doped hydroxyapatite (HA) was prepared via a new ionic liquid-assisted hydrothermal (ILH) route. Samples were characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM)/energy dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), dynamic light scattering (DLS), Brunauer-Emmett-Teller (BET) surface area analysis, and cell viability. The obtained experimental data showed that the nucleation and crystal growth process controlled by [BMIM]Br molecules results in uniform products with small and regular particles and high specific surface areas. Finally, cytotoxicity tests showed that the as-prepared Sr-doped HA nanoparticles have good biocompatibility (≥91%), confirming their potential for use in photo-curable dental restorative composites.
纳米结构羟基磷灰石（HA）是一类新型的生物相容性填料，由于其优异的组织生物活性和生物相容性，最近已被用于生物混合材料中。然而，对更高的热稳定性、溶解性、表面生物活性、射线不透性和再矿化能力的需求表明，可对HA进行二价阳离子取代，以用于光固化牙科修复复合材料。在这项工作中，基于密度泛函理论（DFT）的第一性原理计算研究了掺锶羟基磷灰石的结构和光学性质。接下来，通过一种新的离子液体辅助水热（ILH）路线制备了掺锶羟基磷灰石（HA）。使用X射线衍射（XRD）、扫描电子显微镜（SEM）/能谱（EDS）、傅里叶变换红外光谱（FTIR）、透射电子显微镜（TEM）、动态光散射（DLS）、布鲁诺尔-埃米特-泰勒（BET）表面积分析和细胞活力对样品进行了表征。获得的实验数据表明，由[BMIM]Br分子控制的成核和晶体生长过程产生了具有小而规则颗粒和高比表面积的均匀产物。最后，细胞毒性测试表明，所制备的掺锶HA纳米颗粒具有良好的生物相容性（≥91%），证实了它们在光固化牙科修复复合材料中的应用潜力。
