Department of Pharmacognosy, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu Campus, Nigeria.
Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria.
Nat Prod Res. 2021 Jun;35(11):1909-1913. doi: 10.1080/14786419.2019.1644505. Epub 2019 Jul 25.
The anti-enteroviral activity of three stilbenoids isolated from the leaves of was investigated using the cytopathic effect reduction assay. The stilbenes were inactive against echovirus E13 but showed activity against echoviruses E7 and E19. In particular, vedelianin (), schweinfurthin G () and mappain () elicited antiviral activity on E19 with IC values of 0.0036 nM, 0.018 nM and 0.24 µM, respectively. Vedelianin () showed the best selectivity profile amongst the isolated compounds with selectivity index values of 31 and 216 against E7 and E19, respectively. It is possible these compounds may be responsible for the traditional use of in the treatment of viral infections.
采用细胞病变抑制法，研究了从 叶片中分离得到的三种芪类化合物的抗肠道病毒活性。这些芪类化合物对 ECHO 病毒 E13 没有活性，但对 ECHO 病毒 E7 和 E19 有活性。特别是，vedelianin ()、schweinfurthin G () 和 mappain ()对 E19 的抗病毒活性分别为 0.0036 nM、0.018 nM 和 0.24 μM。Vedelianin ()在分离得到的化合物中表现出最好的选择性，对 E7 和 E19 的选择性指数值分别为 31 和 216。这些化合物可能是 用于治疗病毒感染的传统用途的原因。
