anti-enteroviral activity of stilbenoids isolated from the leaves of .

The anti-enteroviral activity of three stilbenoids isolated from the leaves of was investigated using the cytopathic effect reduction assay. The stilbenes were inactive against echovirus E13 but showed activity against echoviruses E7 and E19. In particular, vedelianin (), schweinfurthin G () and mappain () elicited antiviral activity on E19 with IC values of 0.0036 nM, 0.018 nM and 0.24 µM, respectively. Vedelianin () showed the best selectivity profile amongst the isolated compounds with selectivity index values of 31 and 216 against E7 and E19, respectively. It is possible these compounds may be responsible for the traditional use of in the treatment of viral infections.