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天然和受自然启发的芪类化合物作为抗病毒药物。

Natural and nature-inspired stilbenoids as antiviral agents.

机构信息

Department of Food, Environmental and Nutritional Sciences, Università Degli Studi di Milano, Via Celoria 2, 20133, Milano, Italy.

Department of Food, Environmental and Nutritional Sciences, Università Degli Studi di Milano, Via Celoria 2, 20133, Milano, Italy.

出版信息

Eur J Med Chem. 2020 Sep 15;202:112541. doi: 10.1016/j.ejmech.2020.112541. Epub 2020 Jul 4.

DOI:10.1016/j.ejmech.2020.112541
PMID:32652408
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7335248/
Abstract

Viruses continue to be a major threat to human health. In the last century, pandemics occurred and resulted in significant mortality and morbidity. Natural products have been largely screened as source of inspiration for new antiviral agents. Within the huge class of plant secondary metabolites, resveratrol-derived stilbenoids present a wide structural diversity and mediate a great number of biological responses relevant for human health. However, whilst the antiviral activity of resveratrol has been extensively studied, little is known about the efficacy of its monomeric and oligomeric derivatives. The purpose of this review is to provide an overview of the achievements in this field, with particular emphasis on the source, chemical structures and the mechanism of action of resveratrol-derived stilbenoids against the most challenging viruses. The collected results highlight the therapeutic versatility of stilbene-containing compounds and provide a prospective insight into their potential development as antiviral agents.

摘要

病毒仍然是人类健康的主要威胁。在上个世纪，大流行发生了，并导致了大量的死亡率和发病率。天然产物已被广泛筛选，作为新抗病毒药物的灵感来源。在植物次生代谢产物的巨大类别中，白藜芦醇衍生的芪类化合物具有广泛的结构多样性，并介导了许多与人类健康相关的生物学反应。然而，虽然白藜芦醇的抗病毒活性已得到广泛研究，但对其单体和低聚衍生物的疗效知之甚少。本综述的目的是提供该领域成就的概述，特别强调白藜芦醇衍生芪类化合物的来源、化学结构和作用机制，以对抗最具挑战性的病毒。收集的结果突出了含芪类化合物的治疗多样性，并为它们作为抗病毒药物的潜在开发提供了前瞻性的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/92317c04bdc3/gr19_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/857bcdcdd530/fx1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/b318a7a1b95d/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/c7ba2cfba6bc/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/a96db37920e4/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/d97b0d3f9511/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/4581884fb02c/gr5_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/012f40b051aa/gr6_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/d06d089518e9/gr7_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/d92dcea0e377/gr8_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/a5ffa8fc6f3f/gr9_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/17870fd527fe/gr10_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/bc33be6f9848/gr11_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/be239d1be7ee/gr12_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/324dbf262712/gr13_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/811248bde820/gr14_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/ac3ca4022f52/gr15_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/3386ee413af2/gr16_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/6737490093ba/gr17_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/0bcfef62d57e/gr18_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/92317c04bdc3/gr19_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/857bcdcdd530/fx1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/b318a7a1b95d/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/c7ba2cfba6bc/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/a96db37920e4/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/d97b0d3f9511/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/4581884fb02c/gr5_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/012f40b051aa/gr6_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/d06d089518e9/gr7_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/d92dcea0e377/gr8_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/a5ffa8fc6f3f/gr9_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/17870fd527fe/gr10_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/bc33be6f9848/gr11_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/be239d1be7ee/gr12_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/324dbf262712/gr13_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/811248bde820/gr14_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/ac3ca4022f52/gr15_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/3386ee413af2/gr16_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/6737490093ba/gr17_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/0bcfef62d57e/gr18_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2881/7335248/92317c04bdc3/gr19_lrg.jpg

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