• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

首个用于 TOF-PET 和质子射程验证的切伦科夫光引发铊溴( Cerenkov charge-induction TlBr )探测器。

First Cerenkov charge-induction (CCI) TlBr detector for TOF-PET and proton range verification.

机构信息

Department of Biomedical Engineering, University of California Davis, Davis, CA, United States of America. Author to whom correspondence should be addressed.

出版信息

Phys Med Biol. 2019 Aug 28;64(17):175001. doi: 10.1088/1361-6560/ab35c4.

DOI:10.1088/1361-6560/ab35c4
PMID:31344688
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8187111/
Abstract

Thallium bromide (TlBr) is a semiconductor material and, simultaneously, a good Cerenkov radiator. The performance of a TlBr detector that integrates two different readouts, the charge induction readout and the detection of Cerenkov light, was evaluated. A TlBr detector with dimensions of 4  ×  4  ×  5 mm, with a monolithic cathode and an anode segmented into strips, was manufactured. One of the bare and polished 4  ×  4 mm faces of the detector was coupled to a silicon photomultiplier (SiPM) to read out the Cerenkov light. Simultaneous timing and energy resolutions of  <400 ps full width at half maximum (FWHM) and ~8.5% at 511 keV were measured using the Cerenkov detection and charge induction readouts, respectively. A coincidence time resolution of 330 ps was obtained when selecting Cerenkov events with amplitudes above 70 mV. The combination of both readouts showed the potential to resolve the depth-of-interaction (DOI) positioning, based on the improvement of energy resolution when selecting events with similar electron drift times. This manuscript sets the stage for a new family of semiconductor detectors that combine charge induction readout with the Cerenkov light detection. Such detectors can provide, simultaneously, outstanding timing, energy, and spatial resolution, and will be an excellent fit for applications that require the detection of high-energy gamma photons with high timing accuracy, such as time-of-flight positron emission tomography (TOF-PET) and prompt gamma imaging (PGI) to assess the particle range in hadron therapy.

摘要

溴化铊(TlBr)是一种半导体材料,同时也是一种良好的切伦科夫辐射体。评估了一种集成两种不同读出方式的 TlBr 探测器的性能,这两种读出方式分别是电荷感应读出和切伦科夫光探测。制造了一个尺寸为 4×4×5mm 的 TlBr 探测器,具有整体阴极和分段阳极。探测器的一个裸露和抛光的 4×4mm 面与硅光电倍增管(SiPM)耦合,用于读取切伦科夫光。使用切伦科夫探测和电荷感应读出,分别测量到<400ps 全宽半最大值(FWHM)和~8.5%的 511keV 时的时间和能量分辨率。当选择幅度大于 70mV 的切伦科夫事件时,获得了 330ps 的符合时间分辨率。当选择具有相似电子漂移时间的事件时,两种读出方式的组合显示出具有改善能量分辨率的潜力,从而实现了相互作用深度(DOI)定位。本文为一种新型半导体探测器奠定了基础,该探测器将电荷感应读出与切伦科夫光探测相结合。这种探测器可以同时提供出色的时间、能量和空间分辨率,非常适合需要高时间精度检测高能伽马光子的应用,例如飞行时间正电子发射断层扫描(TOF-PET)和瞬发伽马成像(PGI),以评估粒子在强子治疗中的射程。

相似文献

1
First Cerenkov charge-induction (CCI) TlBr detector for TOF-PET and proton range verification.首个用于 TOF-PET 和质子射程验证的切伦科夫光引发铊溴( Cerenkov charge-induction TlBr )探测器。
Phys Med Biol. 2019 Aug 28;64(17):175001. doi: 10.1088/1361-6560/ab35c4.
2
Energy and electron drift time measurements in a pixel CCI TlBr detector with 1.3 MeV prompt-gammas.在具有1.3 MeV瞬发伽马射线的像素CCI TlBr探测器中进行能量和电子漂移时间测量。
Phys Med Biol. 2021 Feb 2;66(4):044001. doi: 10.1088/1361-6560/abd419.
3
Towards time-of-flight PET with a semiconductor detector.基于半导体探测器的飞行时间正电子发射断层成像。
Phys Med Biol. 2018 Feb 16;63(4):04LT01. doi: 10.1088/1361-6560/aaaa4e.
4
Study of Čerenkov Light Emission in the Semiconductors TlBr and TlCl for TOF-PET.用于TOF-PET的半导体TlBr和TlCl中切伦科夫光发射的研究。
IEEE Trans Radiat Plasma Med Sci. 2021 Sep;5(5):630-637. doi: 10.1109/trpms.2020.3024032. Epub 2020 Sep 17.
5
Development of TlBr detectors for PET imaging.用于正电子发射断层成像术的 TlBr 探测器的研发。
Phys Med Biol. 2018 Jul 3;63(13):13NT04. doi: 10.1088/1361-6560/aac27e.
6
An edge-readout, multilayer detector for positron emission tomography.一种正电子发射断层成像的边沿读出式多层探测器。
Med Phys. 2018 Jun;45(6):2425-2438. doi: 10.1002/mp.12906. Epub 2018 May 6.
7
Performance of long rectangular semi-monolithic scintillator PET detectors.长矩形半整体闪烁体 PET 探测器的性能。
Med Phys. 2019 Apr;46(4):1608-1619. doi: 10.1002/mp.13432. Epub 2019 Feb 20.
8
Effect of detector geometry and surface finish on Cerenkov based time estimation in monolithic BGO detectors.探测器几何形状和表面光洁度对整块锗酸铋探测器中基于切伦科夫效应的时间估计的影响。
Phys Med Biol. 2023 Jan 5;68(2). doi: 10.1088/1361-6560/acabfd.
9
Prompt gamma timing for proton range verification with TlBr and TlCl as pure Cherenkov emitters.用 TlBr 和 TlCl 作为纯切伦科夫发射器进行质子射程验证的快 gamma 定时。
Phys Med Biol. 2024 May 14;69(11):115002. doi: 10.1088/1361-6560/ad4304.
10
Colored reflectors to improve coincidence timing resolution of BGO-based time-of-flight PET detectors.彩色反射器提高基于 BGO 的飞行时间 PET 探测器的符合时间分辨率。
Phys Med Biol. 2023 Sep 8;68(18). doi: 10.1088/1361-6560/acf027.

引用本文的文献

1
Prompt gamma timing for proton range verification with TlBr and TlCl as pure Cherenkov emitters.用 TlBr 和 TlCl 作为纯切伦科夫发射器进行质子射程验证的快 gamma 定时。
Phys Med Biol. 2024 May 14;69(11):115002. doi: 10.1088/1361-6560/ad4304.
2
Cherenkov Light Emission in Pure Cherenkov Emitters for Prompt Gamma Imaging.用于瞬发伽马成像的纯切伦科夫发射体中的切伦科夫光发射
IEEE Trans Radiat Plasma Med Sci. 2024 Jan;8(1):15-20. doi: 10.1109/trpms.2023.3323838. Epub 2023 Oct 13.
3
Timing Estimation and Limits in TOF-PET Detectors Producing Prompt Photons.产生即时光子的TOF-PET探测器中的时间估计与限制
IEEE Trans Radiat Plasma Med Sci. 2023 Sep;7(7):692-703. doi: 10.1109/trpms.2023.3279455. Epub 2023 May 24.
4
The Accuracy of Cerenkov Photons Simulation in Geant4/Gate Depends on the Parameterization of Primary Electron Propagation.Geant4/Gate中切伦科夫光子模拟的准确性取决于初级电子传播的参数化。
Front Phys. 2022;10. doi: 10.3389/fphy.2022.891602. Epub 2022 Apr 28.
5
Study of Annihilation Photon Pair Coincidence Time Resolution Using Prompt Photon Emissions in New Perovskite Bulk Crystals.利用新型钙钛矿块状晶体中的瞬发光子发射研究湮没光子对符合时间分辨率
IEEE Trans Radiat Plasma Med Sci. 2022 Sep;6(7):804-810. doi: 10.1109/trpms.2022.3149992. Epub 2022 Feb 9.
6
Technical opportunities and challenges in developing total-body PET scanners for mice and rats.开发用于小鼠和大鼠的全身正电子发射断层扫描仪(PET)的技术机遇与挑战。
EJNMMI Phys. 2023 Jan 2;10(1):2. doi: 10.1186/s40658-022-00523-6.
7
Study of Čerenkov Light Emission in the Semiconductors TlBr and TlCl for TOF-PET.用于TOF-PET的半导体TlBr和TlCl中切伦科夫光发射的研究。
IEEE Trans Radiat Plasma Med Sci. 2021 Sep;5(5):630-637. doi: 10.1109/trpms.2020.3024032. Epub 2020 Sep 17.
8
Energy Recovery of Multiple Charge Sharing Events in Room Temperature Semiconductor Pixel Detectors.室温半导体像素探测器中多个电荷共享事件的能量恢复
Sensors (Basel). 2021 May 25;21(11):3669. doi: 10.3390/s21113669.
9
Energy and electron drift time measurements in a pixel CCI TlBr detector with 1.3 MeV prompt-gammas.在具有1.3 MeV瞬发伽马射线的像素CCI TlBr探测器中进行能量和电子漂移时间测量。
Phys Med Biol. 2021 Feb 2;66(4):044001. doi: 10.1088/1361-6560/abd419.

本文引用的文献

1
A full-scale clinical prototype for proton range verification using prompt gamma-ray spectroscopy.基于瞬发伽马射线能谱法的质子射程验证全尺寸临床原型。
Phys Med Biol. 2018 Sep 17;63(18):185019. doi: 10.1088/1361-6560/aad513.
2
Development of TlBr detectors for PET imaging.用于正电子发射断层成像术的 TlBr 探测器的研发。
Phys Med Biol. 2018 Jul 3;63(13):13NT04. doi: 10.1088/1361-6560/aac27e.
3
3D prompt gamma imaging for proton beam range verification.基于 3D 提示伽马成像的质子束射程验证。
Phys Med Biol. 2018 Jan 30;63(3):035019. doi: 10.1088/1361-6560/aaa203.
4
Towards time-of-flight PET with a semiconductor detector.基于半导体探测器的飞行时间正电子发射断层成像。
Phys Med Biol. 2018 Feb 16;63(4):04LT01. doi: 10.1088/1361-6560/aaaa4e.
5
Hybrid Pixel-Waveform (HPWF) Enabled CdTe Detectors for Small Animal Gamma-Ray Imaging Applications.用于小动物伽马射线成像应用的启用混合像素波形(HPWF)的碲化镉探测器。
IEEE Trans Radiat Plasma Med Sci. 2017 Jan;1(1):3-14. doi: 10.1109/TNS.2016.2623807. Epub 2016 Nov 1.
6
New-generation small animal positron emission tomography system for molecular imaging.用于分子成像的新一代小动物正电子发射断层扫描系统。
J Med Imaging (Bellingham). 2017 Jan;4(1):011008. doi: 10.1117/1.JMI.4.1.011008. Epub 2017 Jan 12.
7
First Images of a Three-Layer Compton Telescope Prototype for Treatment Monitoring in Hadron Therapy.用于强子治疗中治疗监测的三层康普顿望远镜原型的首批图像。
Front Oncol. 2016 Feb 2;6:14. doi: 10.3389/fonc.2016.00014. eCollection 2016.
8
Measurement of mobility and lifetime of electrons and holes in a Schottky CdTe diode.肖特基碲化镉二极管中电子和空穴迁移率及寿命的测量。
J Instrum. 2014 Dec 1;9:C12032. doi: 10.1088/1748-0221/9/12/C12032.
9
Range assessment in particle therapy based on prompt γ-ray timing measurements.基于瞬发γ射线时间测量的粒子治疗射程评估
Phys Med Biol. 2014 Sep 21;59(18):5399-422. doi: 10.1088/0031-9155/59/18/5399. Epub 2014 Aug 26.
10
Energy and coincidence time resolution measurements of CdTe detectors for PET.用于正电子发射断层扫描(PET)的碲化镉(CdTe)探测器的能量及符合时间分辨率测量
J Instrum. 2013 Feb;8. doi: 10.1088/1748-0221/8/02/C02015.