从红树林来源真菌 sp. TGM112 中分离得到的生物活性内酯。
Bioactive Lactones from the Mangrove-Derived Fungus sp. TGM112.
机构信息
Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan 571158, China.
Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Hainan Normal University, Haikou, Hainan 571158, China.
出版信息
Mar Drugs. 2019 Jul 24;17(8):433. doi: 10.3390/md17080433.
Three new lactones penicilactones A-C (-) were obtained from the mangrove-derived fungus sp. TGM112. Their structures and absolute configurations were determined by detailed NMR, MS spectroscopic data, Mo(OAc)-induced electronic circular dichroism (ECD), and circular dichroism (CD) spectroscopy. Compound showed antibacterial activity against with an MIC value of 6.25 μg/mL. Compound showed insecticidal activity against newly hatched larvae of with the LC value of 78.5 (±0.58) μg/mL.
从红树林来源的真菌 sp. TGM112 中获得了三种新的内酯 penicilactones A-C(-)。通过详细的 NMR、MS 光谱数据、Mo(OAc)-诱导的电子圆二色性 (ECD) 和圆二色性 (CD) 光谱确定了它们的结构和绝对构型。化合物 对 显示出抗菌活性，MIC 值为 6.25 μg/mL。化合物 对刚孵化的 幼虫显示出杀虫活性，LC 值为 78.5(±0.58)μg/mL。
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