Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou, Hainan 571127, China.
Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan 571127, China.
Mar Drugs. 2019 Nov 20;17(12):649. doi: 10.3390/md17120649.
Four new xanthene derivatives, penicixanthenes A-D (-), and one known compound were isolated from a marine mangrove endophytic fungus sp. JY246 that was obtained from the stem of . Their structures were determined by detailed NMR, MS spectroscopic data, modified Mosher's method, and calculated electronic circular dichroism data. All of the isolated compounds were examined for insecticidal activity. Compounds and showed growth inhibition activity against newly hatched larvae of Hubner with the IC values 100 and 200 μg/mL, respectively, and compounds , , and showed insecticidal activity against newly hatched larvae of with LC values of 38.5 (±1.16), 11.6 (±0.58), and 20.5 (±1) μg/mL, respectively. The four xanthene derivatives have the potential to be developed as new biopesticides.
从一株采自中国海南省红树林的内生真菌 sp. JY246 中分离得到四个新的呫吨酮衍生物（penicixanthenes A-D）和一个已知化合物。通过详细的 NMR、MS 谱学数据、改进的 Mosher 法和计算的电子圆二色谱数据确定了它们的结构。所有分离得到的化合物都进行了杀虫活性测试。化合物 和 对刚孵化的 幼虫的生长抑制活性分别为 100 和 200 μg/mL，化合物 、 、和 对刚孵化的 幼虫的杀虫活性分别为 LC 值为 38.5（±1.16）、11.6（±0.58）和 20.5（±1）μg/mL。这四个呫吨酮衍生物具有开发为新型生物农药的潜力。
