Institute of Anatomy, First Faculty of Medicine, Charles University, Prague, Czech Republic; BIOCEV, First Faculty of Medicine, Charles University, Vestec, Czech Republic.
Department of Plastic Surgery, Third Faculty of Medicine, Charles University, Prague, Czech Republic.
Clin Dermatol. 2019 Jul-Aug;37(4):326-335. doi: 10.1016/j.clindermatol.2019.04.005. Epub 2019 Apr 26.
The world population of adults aged 60 years or more is increasing globally, and this development can impact skin disease morbidity and mortality, as well as being reflected in the health care system organization. There is substantial evidence that the burden from a remarkable number of skin nonmalignant and malignant conditions is greater in the elderly. Dermatologic research and clinical education in dermatology should focus on both challenges and opportunities created by aging. Skin aging due to intrinsic and extrinsic factors can alter significantly epidermal and dermal structure and functions. Dermal aging can be linked to a great number of complications in routine dermatologic conditions, with slow healing as an example of a severe complication in the elderly. This may be attributed to aged dermal fibroblasts modifying the tissue microenvironment via a shift in their soluble factors and extracellular matrix repertoire. This senescence-associated secretory phenotype can explain the particular proclivity of aged skin to develop malignancies.
全球 60 岁及以上成年人的人口数量正在增加，这种发展会影响皮肤疾病的发病率和死亡率，并反映在医疗保健系统的组织上。有大量证据表明，老年人患大量非恶性和恶性皮肤疾病的负担更大。皮肤科的皮肤科研究和临床教育应关注由衰老带来的挑战和机遇。由于内在和外在因素导致的皮肤老化会显著改变表皮和真皮的结构和功能。皮肤老化与许多常见皮肤病的并发症有关，其中愈合缓慢就是老年人的一种严重并发症。这可能归因于老年真皮成纤维细胞通过其可溶性因子和细胞外基质谱的改变来改变组织微环境。这种衰老相关的分泌表型可以解释老年皮肤特别容易发生恶性肿瘤的原因。
