Quan Taihao, Fisher Gary J
Department of Dermatology, University of Michigan Medical School, Ann Arbor, Mich., USA.
Gerontology. 2015;61(5):427-34. doi: 10.1159/000371708. Epub 2015 Feb 4.
Human skin is largely composed of a collagen-rich connective tissue, which provides structural and functional support. The collagen-rich connective tissue is produced, organized, and maintained by dermal fibroblasts. During aging, dermal collagen fibrils undergo progressive loss and fragmentation, leading to thin and structurally weakened skin. Age-related alterations of collagen fibrils impairs skin structure and function and creates a tissue microenvironment that promotes age-related skin diseases, such as delayed wound healing and skin cancer development. This mini-review describes cellular mechanisms that give rise to self-perpetuating, collagen fibril fragmentation that creates an age-associated dermal microenvironment, which contributes to decline of human skin function.
人体皮肤主要由富含胶原蛋白的结缔组织构成，该组织提供结构和功能支持。富含胶原蛋白的结缔组织由真皮成纤维细胞产生、组织和维持。在衰老过程中，真皮胶原纤维会逐渐丢失和断裂，导致皮肤变薄且结构变弱。胶原纤维的年龄相关变化会损害皮肤结构和功能，并创造一个促进与年龄相关的皮肤疾病（如伤口愈合延迟和皮肤癌发展）的组织微环境。本综述描述了导致自我持续的胶原纤维断裂的细胞机制，这种断裂产生了与年龄相关的真皮微环境，从而导致人体皮肤功能下降。
