Walsh J T, Deutsch T F
Wellman Laboratories, Department of Dermatology, Massachusetts General Hospital, Boston 02114.
Lasers Surg Med. 1988;8(3):264-75. doi: 10.1002/lsm.1900080308.
Ablation of guinea pig skin using a CO2 laser emitting 2-mu sec-long pulses has been quantified by measuring the mass of tissue removed as a function of incident fluence per pulse. The mass-loss curves show three distinct regimes in which water evaporation, explosive tissue removal, and laser-induced plasma formation dominate. The data are fit to two models that predict that the mass removed depends either linearly or logarithmically on fluence. Although the data are best fit by a linear dependence upon fluence, plasma formation at high fluences prohibited obtaining data over a wide enough fluence range to differentiate unambiguously between the two models. Ablation efficiency, ablation thresholds, and the optical penetration depth at 10.6 micron were obtained from the measurements.
通过测量作为每个脉冲入射能量密度函数的去除组织质量，对使用发射2微秒长脉冲的二氧化碳激光烧蚀豚鼠皮肤进行了量化。质量损失曲线显示出三个不同的区域，其中水蒸发、组织爆炸去除和激光诱导等离子体形成起主导作用。数据拟合到两个模型，这两个模型预测去除的质量要么与能量密度呈线性关系，要么呈对数关系。尽管数据最适合与能量密度呈线性关系，但高能量密度下的等离子体形成使得无法在足够宽的能量密度范围内获取数据，从而无法明确区分这两个模型。从测量中获得了烧蚀效率、烧蚀阈值和10.6微米处的光学穿透深度。
