中国银屑病患病率及相关危险因素的全国性、基于人群的横断面研究方案。
Prevalence of psoriasis and associated risk factors in China: protocol of a nationwide, population-based, cross-sectional study.
机构信息
Institute of Dermatology, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
School of Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
出版信息
BMJ Open. 2019 Jul 24;9(7):e027685. doi: 10.1136/bmjopen-2018-027685.
INTRODUCTION
Psoriasis is a chronic inflammatory skin disease which could lead to serious complications and increased risk of cardiovascular diseases. Psoriasis was recognised as a serious non-communicable disease with important public health impact by member states in the World Health Assembly resolution in 2014. However, data on psoriasis epidemiology are scarce worldwide, especially from low-income and middle-income countries. Only a few epidemiological studies on psoriasis have been conducted in parts of China, mostly without appropriate sampling design and data analysis.
AIM
This study aims to obtain the prevalence of psoriasis in China and relevant risk factors through a nationwide, population-based study with adequate statistical design.
METHODS AND ANALYSIS
This is a cross-sectional study to be conducted in 60 sites across China. A multistage, cluster random sampling design is used. Participants should have local household registration or be residing in the survey area for at least 6 months during the past year. The presence of psoriasis is ascertained independently by two certified dermatologists. If any discrepancies in the diagnosis occur, consensus will be met via discussion. All participants will be interviewed with a questionnaire to collect sociodemographic and disease information. The field survey will be implemented from October 2018 to June 2019. All statistical analyses will be conducted using survey procedures in SAS V.9.2 software to adjust for the complex sample design.
ETHICS AND DISSEMINATION
The study has been reviewed and approved by the ethics committee of the Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College (Nanjing, China). A written informed consent will be obtained from all participants before the questionnaire survey. Findings of the study will be disseminated through publications in peer-reviewed journals.
简介
银屑病是一种慢性炎症性皮肤病，可导致严重并发症，并增加心血管疾病的风险。2014 年，世界卫生大会决议将银屑病确认为具有重要公共卫生影响的严重非传染性疾病。然而，全球范围内银屑病流行病学数据稀缺，尤其是在低收入和中等收入国家。中国部分地区仅有少数银屑病流行病学研究，且大多未进行适当的抽样设计和数据分析。
目的
本研究旨在通过一项全国性、基于人群的研究，采用适当的统计设计，获得中国银屑病的患病率及其相关危险因素。
方法和分析
这是一项在中国 60 个地点进行的横断面研究。采用多阶段、聚类随机抽样设计。参与者应具有当地户籍或在过去一年中在调查地区居住至少 6 个月。由两名认证皮肤科医生独立确定银屑病的存在。如果诊断存在任何差异，将通过讨论达成共识。所有参与者将接受问卷调查，以收集社会人口学和疾病信息。现场调查将于 2018 年 10 月至 2019 年 6 月进行。所有统计分析均将使用 SAS V.9.2 软件中的调查程序进行，以调整复杂的样本设计。
伦理和传播
该研究已由中国医学科学院皮肤病研究所和北京协和医学院伦理委员会审查和批准（中国南京）。在问卷调查前，将向所有参与者获得书面知情同意。研究结果将通过在同行评议期刊上发表论文进行传播。
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