Mahmoud Enji A, Moneim Wesam-Abdel, Shaker Olfat G, Ghalwash Dalia M
Associate professor in Department of Oral Medicine and Periodontology, Faculty of dentistry, Cairo University.
Professor in Department of Biochemistry, Faculty of Medicine, Cairo University.
J Clin Exp Dent. 2019 Jun 1;11(6):e534-e541. doi: 10.4317/jced.55695. eCollection 2019 Jun.
Recurrent aphthous ulcers (RAU) are common painful inflammatory lesions of the mucous lining of the mouth. Endocan, previously identified as endothelial cell specific molecule-1, is implicated as a vital player in the regulation of several inflammatory processes. A number of inflammatory cytokines and pro-angiogenic growth factors including VEGF upregulate endothelial cells synthesis and expression of endocan.
Clinical scores of pain and ulcer size as well as level of endocan and VEGF were determined in swaps from aphthous ulcer and contra lateral normal mucosa in 30 patients (nine males and twenty one females) with age ranging from 18 to 45 years and mean age is 31.5 years.
In the early days of ulcer development, ulcer showed statistically significantly higher mean endocan (8.2 ±5.3) and VEGF levels (1220.7 ±294.6) than control healthy mucosal site (1.1 ±0.5) and (518.6 ± 61.7) respectively. An increase in endocan is associated with an increase in pain score and vice versa. A statistically significant positive correlation were also found between endocan and VEGF levels.
Endocan and VEGF are strongly associated with the destructive phase of minor aphthous ulcers especially Endocan which was positively correlated with pain severity. Endocan, ESM-1, VEGF, Recurrent Apthous Ulcer.
复发性阿弗他溃疡（RAU）是口腔黏膜常见的疼痛性炎性病变。内皮糖蛋白，先前被鉴定为内皮细胞特异性分子-1，被认为是多种炎症过程调节中的重要参与者。包括血管内皮生长因子（VEGF）在内的多种炎性细胞因子和促血管生成生长因子可上调内皮细胞内皮糖蛋白的合成和表达。
对30例年龄在18至45岁之间（平均年龄31.5岁）的患者（9例男性和21例女性），测定阿弗他溃疡及对侧正常黏膜拭子中的疼痛临床评分、溃疡大小以及内皮糖蛋白和VEGF水平。
在溃疡发展早期，溃疡处内皮糖蛋白平均水平（8.2±5.3）和VEGF水平（1220.7±294.6）在统计学上显著高于对照健康黏膜部位（分别为1.1±0.5和518.6±61.7）。内皮糖蛋白增加与疼痛评分增加相关，反之亦然。内皮糖蛋白和VEGF水平之间也存在统计学上显著的正相关。
内皮糖蛋白和VEGF与轻型阿弗他溃疡的破坏期密切相关，尤其是内皮糖蛋白与疼痛严重程度呈正相关。内皮糖蛋白、内皮细胞特异性分子-1、血管内皮生长因子、复发性阿弗他溃疡
