类芬顿试剂降解卤乙酸及 GC-MS 分析：生物检测在遗传毒性、致突变性和细胞毒性监测中的应用。
Degradation of haloacetic acids with the Fenton-like and analysis by GC-MS: use of bioassays for monitoring of genotoxic, mutagenic and cytotoxic effects.
机构信息
Instituto de Ciência, Engenharia e Tecnologia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Teófilo Otoni, MG, 39803-371, Brazil.
Departamento de Engenharia Sanitária e Ambiental, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
出版信息
Environ Monit Assess. 2019 Jul 26;191(8):513. doi: 10.1007/s10661-019-7642-6.
In this study, a method was developed to evaluate the degradation of haloacetic acids (HAAs) in water by a heterogenous Fenton-like process catalyzed by cobalt-doped magnetite nanoparticles (FeCoO), extraction of the contaminants by liquid-liquid extraction (LLE), and analysis by gas chromatography-mass spectrometry (GC-MS). The developed method was efficient in the degradation of HAAs, with the following degradation values: 63%, 62%, 30%, 39%, 37%, 50%, 84%, 41%, and 79% for monochloroacetic acid, monobromoacetic acid, dichloroacetic acid, trichloroacetic acid, bromochloroacetic acid, dibromoacetic acid, bromodichloroacetic acid, dibromochloroacetic acid, and tribromoacetic acid compounds, respectively. Through the application of the Allium cepa test, the cytotoxicity, genotoxicity, and mutagenicity of HAAs were evaluated. The results confirm its genotoxic and mutagenic effects on Allium cepa meristematic cells. Through this study, it was possible to verify the effectiveness of the developed method and its potential as a proposal for environmental remediation.
本研究开发了一种方法，通过钴掺杂磁铁矿纳米粒子（FeCoO）催化的非均相类芬顿反应、液液萃取（LLE）提取污染物以及气相色谱-质谱联用（GC-MS）分析来评估水中卤乙酸（HAAs）的降解情况。所开发的方法在降解 HAAs 方面非常有效，以下是各化合物的降解值：一氯乙酸、一溴乙酸、二氯乙酸、三氯乙酸、溴氯乙酸、二溴乙酸、溴二氯乙酸、二溴氯乙酸和三溴乙酸的降解值分别为 63%、62%、30%、39%、37%、50%、84%、41%和 79%。通过应用洋葱根尖细胞试验，评估了 HAAs 的细胞毒性、遗传毒性和致突变性。结果证实了其对洋葱根尖细胞有遗传毒性和致突变性。通过这项研究，验证了所开发方法的有效性及其作为环境修复提案的潜力。
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