State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. R. China.
Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
Adv Mater. 2019 Sep;31(37):e1903013. doi: 10.1002/adma.201903013. Epub 2019 Jul 25.
Silicon-based biomaterials play an indispensable role in biomedical engineering; however, due to the lack of intrinsic functionalities of silicon, the applications of silicon-based nanomaterials are largely limited to only serving as carriers for drug delivery systems. Meanwhile, the intrinsically poor biodegradation nature for silicon-based biomaterials as typical inorganic materials also impedes their further in vivo biomedical use and clinical translation. Herein, by the rational design and wet chemical exfoliation synthesis of the 2D silicene nanosheets, traditional 0D nanoparticulate nanosystems are transformed into 2D material systems, silicene nanosheets (SNSs), which feature an intriguing physiochemical nature for photo-triggered therapeutics and diagnostic imaging and greatly favorable biological effects of biocompatibility and biodegradation. In combination with DFT-based molecular dynamics (MD) calculations, the underlying mechanism of silicene interactions with bio-milieu and its degradation behavior are probed under specific simulated physiological conditions. This work introduces a new form of silicon-based biomaterials with 2D structure featuring biodegradability, biocompatibility, and multifunctionality for theranostic nanomedicine, which is expected to promise high clinical potentials.
基于硅的生物材料在生物医学工程中起着不可或缺的作用；然而，由于硅缺乏内在功能，基于硅的纳米材料的应用在很大程度上仅限于作为药物输送系统的载体。同时，作为典型的无机材料，基于硅的生物材料内在较差的生物降解性也阻碍了它们在体内生物医学应用和临床转化中的进一步应用。在此，通过对二维硅烯纳米片的合理设计和湿化学剥离合成，将传统的 0D 纳米颗粒纳米系统转变为具有光触发治疗和诊断成像的有趣物理化学性质的二维材料系统——硅烯纳米片（SNS），并具有良好的生物相容性和生物降解性。结合基于密度泛函理论的分子动力学（MD）计算，在特定模拟生理条件下，研究了硅烯与生物环境相互作用及其降解行为的潜在机制。这项工作为治疗诊断纳米医学引入了一种具有生物降解性、生物相容性和多功能性的新型二维结构的基于硅的生物材料，有望具有很高的临床应用潜力。
