State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China; School of Physical Science and Technology, ShanghaiTech University, Shanghai, 201210, PR China.
State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China; Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, PR China.
Biomaterials. 2021 Nov;278:121172. doi: 10.1016/j.biomaterials.2021.121172. Epub 2021 Oct 4.
Silicon, a highly biocompatible and ubiquitous chemical element in living systems, exhibits great potentials in biomedical applications. However, the silicon-based nanomaterials such as silica and porous silicon have been largely limited to only serving as carriers for delivery systems, due to the lack of intrinsic functionalities of silicon. This work presents the facile construction of a two-dimensional (2D) hydrogen-bonded silicene (H-silicene) nanosystem which is highlighted with tunable bandgap and selective degradability for tumor-specific photodynamic therapy facilely by surface covalent modification of hydrogen atoms. Briefly, the H-silicene nanosheet material is selectively degradable in normal neutral tissues but rather stable in the mildly acidic tumor microenvironment (TME) for achieving efficient photodynamic therapy (PDT). Such a 2D hydrogen-bonded silicene nanosystem featuring the tunable bandgap and tumor-selective degradability provides a new paradigm for the application of multi-functional two-dimensional silicon-based biomaterials towards the diagnosis and treatments of cancer and other diseases.
硅作为生命系统中一种高度生物相容和普遍存在的化学元素，在生物医学应用中具有巨大的潜力。然而，由于硅本身缺乏内在功能，基于硅的纳米材料，如二氧化硅和多孔硅，在很大程度上仅限于作为输送系统的载体。本工作提出了一种简便的二维（2D）氢键硅烯（H-silicene）纳米系统的构建方法，该系统通过表面共价修饰氢原子，具有可调带隙和肿瘤特异性光动力治疗的选择性降解能力。简而言之，H-silicene 纳米片材料在正常中性组织中具有选择性降解性，但在轻度酸性肿瘤微环境（TME）中相当稳定，可实现高效光动力治疗（PDT）。这种具有可调带隙和肿瘤选择性降解性的二维氢键硅烯纳米系统为多功能二维硅基生物材料在癌症和其他疾病的诊断和治疗中的应用提供了新的范例。
