Duan Huican, Chang Meiqi, Lin Han, Huang Hui, Feng Wei, Guo Weitao, Wu Lina, Chen Yu, Zhang Ruifang
Department of Ultrasound, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, PR China.
Central Laboratory of Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, PR China.
Mater Today Bio. 2022 Aug 12;16:100393. doi: 10.1016/j.mtbio.2022.100393. eCollection 2022 Dec.
Since the innovative development of photosensitizers (PSs) is pivotal prerequisite for the successful clinical translation of photodynamic therapy (PDT), the unresolved challenges of classical PSs such as photobleaching, poor bioavailability, lack of tumor selectivity encourage the exploitation of new-generation PSs. In this work, we develop silicene nanosheets with unparalleled physiochemical nature and intriguing biocompatibility as the distinct two-dimensional (2D) nanoscale photosensitizer based on the mechanism of wet-chemical synthetic approach to achieve effective PDT-based tumor nanotherapy. The generation capacities of singlet oxygen (O) in different atmospheres have been systematically explored in depth. Furthermore, the conjunction of c (RGDyC) onto 2D silicene nanosheets (denoted as SRGD) endows the SRGD nanomedicines with specific targeting properties to integrin-overexpressed cancer cells, accomplishing potent tumor growth inhibition efficiency. More notably, the excellent light absorption capacity of 2D silicene enables the tumor-specific photoacoustic imaging for potentiating the therapeutic guidance and monitoring. This paradigm can inspire the future design and applications of 2D silicene-based cancer-theranostic nanoplatform in biology and medicine.
由于光敏剂（PSs）的创新发展是光动力疗法（PDT）成功临床转化的关键前提，传统PSs存在的诸如光漂白、生物利用度差、缺乏肿瘤选择性等未解决的挑战促使人们开发新一代PSs。在这项工作中，我们基于湿化学合成方法的机制，开发了具有无与伦比的物理化学性质和有趣生物相容性的硅烯纳米片，作为独特的二维（2D）纳米级光敏剂，以实现基于PDT的有效肿瘤纳米治疗。我们深入系统地探索了不同气氛下单线态氧（O）的生成能力。此外，将c（RGDyC）连接到二维硅烯纳米片上（表示为SRGD），赋予SRGD纳米药物对整合素过表达癌细胞的特异性靶向特性，实现了强大的肿瘤生长抑制效率。更值得注意的是，二维硅烯出色的光吸收能力使其能够进行肿瘤特异性光声成像，以加强治疗指导和监测。这种范例可以启发未来基于二维硅烯的癌症诊疗纳米平台在生物学和医学中的设计与应用。
