General Hospital Murska Sobota, Ulica dr. Vrbnjaka 6, Rakican, SI-9000, Murska Sobota, Slovenia.
Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
ESC Heart Fail. 2019 Oct;6(5):1077-1084. doi: 10.1002/ehf2.12496. Epub 2019 Jul 25.
Epidemiological heart failure (HF) data in the era of natriuretic peptides and echocardiography are scarce. The primary aim of this study is to evaluate the HF prevalence in the general population. We will also investigate natriuretic peptide cut-off for diagnosis of HF. Finally, we will be able to identify left ventricular function phenotypes and study relations between cardiac function, clinical presentation, and health-related quality of life.
Screening Of adult urBan pOpulation To diAgnose Heart Failure (SOBOTA-HF) is a cross-sectional prevalence study in a representative sample of Murska Sobota residents aged 55 years or more. Individuals will be invited to attend screening visit with point-of-care N-terminal pro-b-type natriuretic peptide (NT-proBNP) testing. All subjects with NT-proBNP ≥ 125 pg/mL will be invited for a diagnostic visit that will include history and physical examination, electrocardiogram, echocardiography, blood and urine sampling, ankle brachial index, pulmonary function tests, body composition measurement, physical performance tests, and questionnaires. To validate the screening procedure, a control group (NT-proBNP < 125 pg/mL) will undergo the same diagnostic evaluation. An external centre will validate echocardiography results, and the HF diagnosis will be adjudicated within an international HF expert panel. Overall and age-specific HF prevalence will be calculated in individuals ≥ 55 years and extrapolated to the whole population.
The SOBOTA-HF study will test the latest HF guideline diagnostic criteria in the general population sample. Next to HF prevalence, it will provide insight into left ventricular function and general patient phenotype; we will also extend current understanding of natriuretic peptides for HF screening.
在利钠肽和超声心动图时代，有关心力衰竭（HF）的流行病学数据较为匮乏。本研究的主要目的是评估一般人群中 HF 的患病率。我们还将研究利钠肽诊断 HF 的截断值。最后，我们将能够确定左心室功能表型，并研究心脏功能、临床表现和健康相关生活质量之间的关系。
筛查城市中老年人群以诊断心力衰竭（SOBOTA-HF）是一项在 Murska Sobota 代表性 55 岁及以上居民中进行的横断面患病率研究。将邀请符合条件的个体参加包含即时检测 N 末端 pro-B 型利钠肽（NT-proBNP）检测的筛查访问。所有 NT-proBNP≥125pg/ml 的受试者将被邀请参加诊断访问，其中包括病史和体格检查、心电图、超声心动图、血液和尿液采样、踝臂指数、肺功能检查、身体成分测量、身体机能测试和问卷调查。为了验证筛查程序，将设立一个对照组（NT-proBNP<125pg/ml），并对其进行相同的诊断评估。一个外部中心将验证超声心动图结果，HF 诊断将由一个国际 HF 专家小组进行裁定。≥55 岁人群的总患病率和年龄特异性 HF 患病率将进行计算，并外推至整个人群。
SOBOTA-HF 研究将在一般人群样本中检验最新的 HF 指南诊断标准。除 HF 患病率外，该研究还将深入了解左心室功能和一般患者表型；我们还将扩展目前对利钠肽在 HF 筛查中的认识。
