Nakanishi I, Kajikawa K, Migita S, Mai M, Akimoto R, Mura T
Cancer. 1982 May 15;49(10):2025-8. doi: 10.1002/1097-0142(19820515)49:10<2025::aid-cncr2820491014>3.0.co;2-x.
A case of IgG (lambda) secreting plasmacytoma arising in the stomach has been presented. Immunohistochemically, the tumor cells contained IgG-lambda immunoglobulin. Immunoelectrophoretic study on patient's serum revealed in the gamma zone the presence of M protein which reacted specifically with anti-IgG and anti-lambda antisera. Agar electrophoresis and immunofixation electrophoresis with anti-IgG and anti-lambda antisera showed multiple subbands. Neuraminidase treatment of the purified IgG from this patient resulted in gradual reduction of four subbands to two. Electrophoretic charge difference of the monoclonal immunoglobulin may be attributed to incompletely synthesized sugar chains attached to the protein core.
本文报道了1例发生于胃的分泌IgG（λ）的浆细胞瘤。免疫组织化学检查显示，肿瘤细胞含有IgG-λ免疫球蛋白。对患者血清进行免疫电泳研究，结果显示在γ区存在M蛋白，该蛋白能与抗IgG和抗λ抗血清发生特异性反应。用抗IgG和抗λ抗血清进行琼脂糖电泳和免疫固定电泳显示有多个亚带。用神经氨酸酶处理该患者纯化的IgG后，4个亚带逐渐减少为2个。单克隆免疫球蛋白的电泳电荷差异可能归因于连接在蛋白质核心上的糖链合成不完全。
